Siddiqui Emad J, Thompson Cecil S, Mikhailidis Dimitri P, Mumtaz Faiz H
Department of Surgery, Royal Free Hospital and University College Medical School, University College London, Pond Street, Hampstead, London NW3 2QG, UK.
Oncol Rep. 2005 Dec;14(6):1593-7.
Serotonin (5-hydroxytryptamine; 5HT) a monoamine neurotransmitter mediates a wide range of physiological actions in the human body. For example 5HT is implicated in psychiatric and neurological disorders and also plays a fundamental role in tumour growth, differentiation and gene expression. 5HT acts as a growth factor for several types of tumoural and non-tumoural cells. This review considers the role of 5HT and its receptors in the human body with particular reference to carcinogenesis. We conclude that 5HT causes growth proliferation and 5HT antagonists cause growth inhibition in a variety of tumour cells (e.g. prostate carcinoma, lung carcinoma and colonic carcinoma). Therefore, further studies should look into the potential use of 5HT antagonists in the treatment of cancer.
血清素（5-羟色胺；5HT）作为一种单胺神经递质，介导人体多种生理活动。例如，5HT与精神和神经疾病有关，在肿瘤生长、分化和基因表达中也发挥着重要作用。5HT作为多种肿瘤细胞和非肿瘤细胞的生长因子。本综述探讨了5HT及其受体在人体中的作用，特别涉及致癌作用。我们得出结论，5HT可导致多种肿瘤细胞（如前列腺癌、肺癌和结肠癌）的生长增殖，而5HT拮抗剂则可导致生长抑制。因此，进一步的研究应探讨5HT拮抗剂在癌症治疗中的潜在用途。
