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Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers.在SiSo细胞上表达的受体结合癌抗原可在胃肠道癌转移淋巴结中检测到。
World J Gastroenterol. 2005 Oct 14;11(38):6014-7. doi: 10.3748/wjg.v11.i38.6014.
2
The utility of serum receptor-binding cancer antigen expressed on SiSo cells in gastrointestinal tract cancers.SiSo细胞上表达的血清受体结合癌抗原在胃肠道癌症中的效用。
Can J Gastroenterol. 2006 Sep;20(9):593-6. doi: 10.1155/2006/276247.
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Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer.宫颈癌中RCAS1表达与微环境免疫细胞死亡之间的关联
Gynecol Oncol. 2005 Jun;97(3):772-9. doi: 10.1016/j.ygyno.2005.02.025. Epub 2005 Apr 15.
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A clinical and immunohistochemical study on gastrointestinal mesenchymal tumor (GIMT): RCAS1 as a predictor for recurrence of GIMT.胃肠道间质瘤（GIMT）的临床与免疫组化研究：RCAS1作为GIMT复发的预测指标
Oncol Rep. 2005 Nov;14(5):1127-32.
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RCAS1 as a tumour progression marker: an independent negative prognostic factor in gallbladder cancer.RCAS1作为肿瘤进展标志物：胆囊癌的独立阴性预后因素。
Br J Cancer. 2001 Dec 14;85(12):1922-7. doi: 10.1054/bjoc.2001.2192.
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Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer.SiSo细胞上表达的受体结合癌抗原（RCAS1）作为人类子宫癌中通过血管生成调节肿瘤生长的关键因子的生物学意义。
Cancer. 2007 Nov 1;110(9):1979-90. doi: 10.1002/cncr.23015.
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Aberrant intracellular localization of RCAS1 is associated with tumor progression of gastric cancer.RCAS1的异常细胞内定位与胃癌的肿瘤进展相关。
Int J Oncol. 2001 Oct;19(4):695-700. doi: 10.3892/ijo.19.4.695.
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Expression of RCAS1 and its function in human squamous cell carcinoma of the oral cavity.RCAS1在口腔鳞状细胞癌中的表达及其功能
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[Expressions of receptor-binding cancer antigen expressed on SiSo cells, vascular endothelial growth factor, and matrix metalloproteinase-9 in cervical carcinoma and correlation thereof with the invasion and metastasis of the cancerous tissues].[SiSo细胞上表达的受体结合癌抗原、血管内皮生长因子及基质金属蛋白酶-9在宫颈癌中的表达及其与癌组织侵袭和转移的相关性]
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High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker.肿瘤相关抗原RCAS1在胰腺导管腺癌中的高表达是一种不良预后标志物。
Int J Cancer. 2002 May 20;99(3):418-23. doi: 10.1002/ijc.10381.

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Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma.肿瘤相关抗原RCAS1在口腔鳞状细胞癌中的凋亡功能
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本文引用的文献

1
Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of patients with surgically-removed gastric carcinoma.肿瘤阳性率及胃周淋巴结数量与手术切除胃癌患者预后的相关性
World J Gastroenterol. 2004 Jan 15;10(2):182-5. doi: 10.3748/wjg.v10.i2.182.
2
Occult neoplastic cells in the lymph node sinuses and recurrence of primary breast, lung, esophageal, and gastric cancer.淋巴结窦中的隐匿性肿瘤细胞与原发性乳腺癌、肺癌、食管癌和胃癌的复发
Oncol Rep. 2004 Jan;11(1):81-4.
3
The relevance of occult axillary micrometastasis in ductal carcinoma in situ: a clinicopathologic study with long-term follow-up.导管原位癌中隐匿性腋窝微转移的相关性：一项长期随访的临床病理研究
Cancer. 2003 Nov 15;98(10):2105-13. doi: 10.1002/cncr.11761.
4
Upregulation of tumour associated antigen RCAS1 is implicated in high stages of colorectal cancer.肿瘤相关抗原RCAS1的上调与结直肠癌的晚期阶段有关。
J Clin Pathol. 2003 Oct;56(10):764-8. doi: 10.1136/jcp.56.10.764.
5
Cytokeratin staining and other sentinel node controversies.细胞角蛋白染色及其他前哨淋巴结相关争议
Clin Breast Cancer. 2003 Apr;4 Suppl 1:S49-54. doi: 10.3816/cbc.2003.s.015.
6
Minimum number of lymph nodes that should be examined for the International Union Against Cancer/American Joint Committee on Cancer TNM classification of gastric carcinoma.国际抗癌联盟/美国癌症联合委员会胃癌TNM分类中应检查的最少淋巴结数量。
World J Surg. 2003 Mar;27(3):330-3. doi: 10.1007/s00268-002-6730-9. Epub 2003 Feb 27.
7
Expression and diagnostic evaluation of the human tumor-associated antigen RCAS1 in pancreatic cancer.人肿瘤相关抗原RCAS1在胰腺癌中的表达及诊断评估
Pancreas. 2003 Jan;26(1):49-55. doi: 10.1097/00006676-200301000-00009.
8
The expression of RCAS1 and tumor infiltrating lymphocytes in patients with T3 gastric carcinoma.T3期胃癌患者中RCAS1与肿瘤浸润淋巴细胞的表达情况
Gastric Cancer. 2002;5(4):220-7. doi: 10.1007/s101200200038.
9
The tumor-associated antigen, RCAS1, can be expressed in immune-mediated diseases as well as in carcinomas of biliary tract.肿瘤相关抗原RCAS1可在免疫介导性疾病以及胆管癌中表达。
J Hepatol. 2002 Jun;36(6):786-92. doi: 10.1016/s0168-8278(02)00066-1.
10
RCAS1 expression as a prognostic factor after curative surgery for extrahepatic bile duct carcinoma.肝外胆管癌根治性切除术后RCAS1表达作为预后因素
Ann Surg Oncol. 2002 May;9(4):388-93. doi: 10.1007/BF02573874.

在SiSo细胞上表达的受体结合癌抗原可在胃肠道癌转移淋巴结中检测到。

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers.

作者信息

Leelawat Kawin, Engprasert Surang, Tujinda Supathip, Suthippintawong Cheepsumon, Enjoji Munechika, Nakashima Manabu, Watanabe Takeshi, Leardkamolkarn Vijittra

机构信息

Department of Surgery, Rajavithi Hospital, Rajavithi Road, Rajathevi, Bangkok 10400, Thailand.

出版信息

World J Gastroenterol. 2005 Oct 14;11(38):6014-7. doi: 10.3748/wjg.v11.i38.6014.

DOI:10.3748/wjg.v11.i38.6014
PMID:16273616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4436726/
Abstract

AIM

To investigate the expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in metastatic lymph nodes from gastrointestinal cancer.

METHODS

Metastatic lymph nodes from gastrointestinal cancer were detected for RCAS1 by immunohistochemical staining and mRNA in situ hybridization.

RESULTS

A total of 102 metastatic lymph nodes from bile duct, gastric, colon and pancreatic cancer were investigated for RCAS1 expression. The immunoreactivity of RCAS1 was identified in 100% of metastatic lymph nodes. Both local and distant metastatic lymph nodes showed RCAS1 expression. On the contrary, specimens of non-cancerous lymph nodes were negative for RCAS1. The result of mRNA in situ hybridization was also confirmed by the finding of immunohistochemical staining. RCAS1 mRNA was detected in all tumor cells that metastasized to lymph nodes.

CONCLUSION

All metastatic lymph nodes express RCAS1 in tumor cells at both mRNA levels, and RCAS1 that should be used as a complementary factor for identification of metastatic lymph nodes from gastrointestinal cancers.

摘要

目的

研究SiSo细胞上表达的受体结合癌抗原（RCAS1）在胃肠道癌转移淋巴结中的表达情况。

方法

采用免疫组织化学染色和mRNA原位杂交法检测胃肠道癌转移淋巴结中的RCAS1。

结果

共对102个来自胆管癌、胃癌、结肠癌和胰腺癌的转移淋巴结进行了RCAS1表达检测。100%的转移淋巴结中均检测到RCAS1的免疫反应性。局部和远处转移淋巴结均有RCAS1表达。相反，非癌性淋巴结标本中RCAS1呈阴性。mRNA原位杂交结果也得到了免疫组织化学染色结果的证实。在所有转移至淋巴结的肿瘤细胞中均检测到RCAS1 mRNA。

结论

所有转移淋巴结中的肿瘤细胞在mRNA水平均表达RCAS1，RCAS1可作为鉴别胃肠道癌转移淋巴结的一个补充指标。