慢性丙型肝炎病毒感染与肝移植后糖尿病
Chronic hepatitis C virus infection and post-liver transplantation diabetes mellitus.
作者信息
Ma Yun, Yan Wen-Wei
机构信息
Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, China.
出版信息
World J Gastroenterol. 2005 Oct 21;11(39):6085-9. doi: 10.3748/wjg.v11.i39.6085.
Abstract
Patients with chronic hepatitis C virus (HCV) infection have a significantly increased prevalence of type 2 diabetes mellitus compared to controls or HBV-infected patients. Moreover, the incidence rate of post-liver transplantation diabetes mellitus (PTDM) also appears to be higher among patients with HCV infection. PTDM is often associated with direct viral infection, autoimmune disorders, and immunosuppressive regimen. Activation of tumor necrosis factor-alpha may be the link between HCV infection and diabetes. In this article, we reviewed the epidemiologic association between HCV infection and PTDM, highlighting the most recent pathophysiologic insights into the mechanisms underlying this association.
摘要
与对照组或乙型肝炎病毒（HBV）感染患者相比，慢性丙型肝炎病毒（HCV）感染患者患2型糖尿病的患病率显著增加。此外，肝移植后糖尿病（PTDM）的发病率在HCV感染患者中似乎也更高。PTDM通常与直接病毒感染、自身免疫性疾病和免疫抑制方案有关。肿瘤坏死因子-α的激活可能是HCV感染与糖尿病之间的联系。在本文中，我们回顾了HCV感染与PTDM之间的流行病学关联，重点介绍了对这种关联潜在机制的最新病理生理学见解。
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