Krauser Daniel G, Segal Alan Z, Kligfield Paul
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University and the Cornell Campus of The New York-Presbyterian Hospital, New York, NY, USA.
Am J Cardiol. 2005 Nov 15;96(10):1463-4. doi: 10.1016/j.amjcard.2005.06.093. Epub 2005 Sep 29.
Neurologic toxicity is an infrequently reported and under-recognized consequence of amiodarone, symptoms of which may include tremor, peripheral sensorimotor neuropathy, proximal weakness, and ataxia. The investigators report the rapid and complete remission of 4 months of progressively debilitating ataxia with the discontinuation of small-dose amiodarone in an elderly woman with hypertrophic obstructive cardiomyopathy and paroxysmal atrial fibrillation. Despite the long half-life of amiodarone, her symptoms began to reduce after several days, and she was walking without assistance within 1 week. Wider recognition of this syndrome may avoid unnecessary and lengthy diagnostic evaluation and promote earlier neurologic recovery.
神经毒性是胺碘酮一种较少被报道且未得到充分认识的后果，其症状可能包括震颤、周围感觉运动神经病变、近端肌无力和共济失调。研究人员报告了一名患有肥厚性梗阻性心肌病和阵发性心房颤动的老年女性，在停用小剂量胺碘酮后，持续4个月逐渐加重的共济失调迅速且完全缓解。尽管胺碘酮半衰期长，但她的症状在数天后开始减轻，1周内就能独立行走。对该综合征更广泛的认识可能会避免不必要且冗长的诊断评估，并促进神经功能更早恢复。
