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胺碘酮致共济失调:严重小脑功能障碍病例报告及文献复习。

Amiodarone-induced Ataxia: A Case Report of Severe Cerebellar Dysfunction and Review of Literature.

机构信息

Gabor Abellan Van Kan, Toulouse University Hospital. Geriatric Department. 224 Avenue de Casselardit. 31059 Toulouse, France,

出版信息

J Nutr Health Aging. 2021;25(3):284-286. doi: 10.1007/s12603-020-1475-4.

DOI:10.1007/s12603-020-1475-4
PMID:33575717
Abstract

Amiodarone therapy is widely prescribed in patients with atrial fibrillation. The higher prevalence of this arrhythmic heart disease, and the specific age-related issues of homeostasis in the elderly population, makes this group particularly exposed to its adverse effects. Among the many described side-effects, neurological impairments are the less documented and studied. Because amiodarone can be responsible for severe complications, as described in the case below, a close monitoring is necessary throughout its prescription. Awareness should be brought on the amiodarone-induced neurological side-effects as they could be overlooked.

摘要

胺碘酮广泛用于治疗心房颤动患者。这种心律失常性心脏病的患病率较高,老年人群体的内稳态与年龄相关的特定问题使得这一人群特别容易受到其不良反应的影响。在许多描述的副作用中,神经损伤的记录和研究较少。由于胺碘酮可能导致严重的并发症,如下文所述,因此在整个处方过程中都需要密切监测。应该注意胺碘酮引起的神经副作用,因为它们可能会被忽视。

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J Nutr Health Aging. 2021;25(3):284-286. doi: 10.1007/s12603-020-1475-4.
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Ataxias: Hereditary, Acquired, and Reversible Etiologies.共济失调:遗传性、获得性和可复发性病因。
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Myoclonic Jerks and Ataxia: A Case of Rare Neurological Side Effects of Amiodarone.肌阵挛性抽搐与共济失调:一例胺碘酮罕见神经副作用病例

本文引用的文献

1
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.2016年欧洲心脏病学会(ESC)与欧洲心胸外科学会(EACTS)合作制定的心房颤动管理指南。
Eur Heart J. 2016 Oct 7;37(38):2893-2962. doi: 10.1093/eurheartj/ehw210. Epub 2016 Aug 27.
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Amiodarone biokinetics, the formation of its major oxidative metabolite and neurotoxicity after acute and repeated exposure of brain cell cultures.胺碘酮的生物动力学、其主要氧化代谢产物的形成以及脑细胞培养物急性和反复暴露后的神经毒性。
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Ataxia: a diagnostic perplexity and management dilemma.
Cureus. 2022 Aug 25;14(8):e28412. doi: 10.7759/cureus.28412. eCollection 2022 Aug.
共济失调:诊断难题与管理困境。
BMJ Case Rep. 2013 Sep 26;2013:bcr2013200575. doi: 10.1136/bcr-2013-200575.
4
Frequency, characteristics, and risk factors for amiodarone neurotoxicity.胺碘酮神经毒性的发生率、特征及危险因素。
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5
Amiodarone-induced neuromyopathy: three cases and a review of the literature.胺碘酮诱发的神经肌肉病:三例报告并文献复习
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Ataxia caused by amiodarone in older people.老年人中胺碘酮所致的共济失调。
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Vitamin E reduces accumulation of amiodarone and desethylamiodarone and inhibits phospholipidosis in cultured human cells.维生素E可减少胺碘酮和去乙基胺碘酮的蓄积,并抑制培养的人细胞中的磷脂质病。
Biochem Pharmacol. 1995 Jun 16;49(12):1741-5. doi: 10.1016/0006-2952(95)00100-e.
9
In vitro inhibition of lysosomal phospholipase A1 of rat lung by amiodarone and desethylamiodarone.胺碘酮和去乙基胺碘酮对大鼠肺溶酶体磷脂酶A1的体外抑制作用。
Biochim Biophys Acta. 1988 Apr 15;959(3):316-21. doi: 10.1016/0005-2760(88)90205-6.