Surette M E, Whelan J, Broughton K S, Kinsella J E
Lipids Research Laboratory, Cornell University, Ithaca, NY.
Biochim Biophys Acta. 1992 Jun 22;1126(2):199-205. doi: 10.1016/0005-2760(92)90291-3.
Ingestion of modest amounts of n-3 polyunsaturated fatty acids (PUFA) (2.8% w/w) decreased plasma triglyceride levels in Syrian hamsters by 49%. This was associated with a 45% increase in hepatic carnitine palmitoyl transferase activity. Significantly, at this low level of n-3 PUFA intake, hepatic peroxisomal oxidation measured as CN- insensitive palmitoyl-CoA dependent NAD reduction was unaffected. Consumption of increasing amounts of dietary n-3 PUFA up to 2% (w/w) in hamster diets containing 15% fat, gradually decreased plasma triglycerides to 56% of the control levels. The diet induced changes in plasma triglyceride levels were highly correlated (r = -0.97, P less than 0.01) with changes in hepatic carnitine palmitoyl transferase activity. A gradual decrease up to 59% in hepatic phosphatidate phosphohydrolase activity with n-3 fatty acid consumption was also observed. The hypotriglyceridemic effects of moderate intakes of n-3 fatty acids are, therefore, associated with changes in key enzymes in hepatic triglyceride synthesis and mitochondrial oxidation, but not peroxisomal oxidation.
摄入适量的n-3多不饱和脂肪酸（PUFA）（2.8%重量/重量）可使叙利亚仓鼠的血浆甘油三酯水平降低49%。这与肝脏肉碱棕榈酰转移酶活性增加45%有关。值得注意的是，在这种低水平的n-3 PUFA摄入量下，以对氰化物不敏感的棕榈酰辅酶A依赖性NAD还原测量的肝脏过氧化物酶体氧化未受影响。在含15%脂肪的仓鼠饮食中，将膳食中n-3 PUFA的摄入量增加至2%（重量/重量），血浆甘油三酯逐渐降至对照水平的56%。饮食引起的血浆甘油三酯水平变化与肝脏肉碱棕榈酰转移酶活性变化高度相关（r = -0.97，P < 0.01）。还观察到随着n-3脂肪酸摄入，肝脏磷脂酸磷酸水解酶活性逐渐降低高达59%。因此，适量摄入n-3脂肪酸的降甘油三酯作用与肝脏甘油三酯合成和线粒体氧化中的关键酶变化有关，但与过氧化物酶体氧化无关。
