Conn P Jeffrey, Battaglia Giuseppe, Marino Michael J, Nicoletti Ferdinando
Program in Translational Neuropharmacology, Department of Pharmacology, Vanderbilt University Medical Center, 23rd Avenue South at Pierce, 417-D Preson Research Building, Nashville, Tennessee 37232-6600, USA.
Nat Rev Neurosci. 2005 Oct;6(10):787-98. doi: 10.1038/nrn1763.
In recent years there have been tremendous advances in our understanding of the circuitry of the basal ganglia and our ability to predict the behavioural effects of specific cellular changes in this circuit on voluntary movement. These advances, combined with a new understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia, indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders.
近年来，我们对基底神经节回路的理解以及预测该回路中特定细胞变化对自主运动行为影响的能力取得了巨大进展。这些进展，再加上对代谢型谷氨酸受体在基底神经节中丰富分布和多样生理作用的新认识，表明这些受体可能在运动控制中起关键作用，并带来了令人兴奋的可能性，即它们可能为帕金森病及相关疾病的治疗提供治疗靶点。
