Richardson U I, Wurtman R J
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Biochim Biophys Acta. 1992 Jul 9;1127(1):99-102. doi: 10.1016/0005-2760(92)90207-c.
Synthesis of phosphatidyl serine by base-exchange and DNA synthesis both declined rapidly in mouse fibroblast cultures upon withdrawal of serum from nutrient medium. Base-exchange returned to control levels within 3 h after the addition of serum, while DNA synthesis lagged by 10 h. Phosphatidyl serine synthesis is thus an early response of 3T6 cells to mitogenic signals.
在从营养培养基中去除血清后，小鼠成纤维细胞培养物中通过碱基交换合成磷脂酰丝氨酸和DNA合成均迅速下降。添加血清后3小时内，碱基交换恢复到对照水平，而DNA合成滞后10小时。因此，磷脂酰丝氨酸合成是3T6细胞对促有丝分裂信号的早期反应。
