3T6小鼠成纤维细胞中的碱基置换与细胞生长
Base-exchange and cell growth in 3T6 mouse fibroblasts.
作者信息
Richardson U I, Wurtman R J
机构信息
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Biochim Biophys Acta. 1992 Jul 9;1127(1):99-102. doi: 10.1016/0005-2760(92)90207-c.
PMID:1627640
Abstract
Synthesis of phosphatidyl serine by base-exchange and DNA synthesis both declined rapidly in mouse fibroblast cultures upon withdrawal of serum from nutrient medium. Base-exchange returned to control levels within 3 h after the addition of serum, while DNA synthesis lagged by 10 h. Phosphatidyl serine synthesis is thus an early response of 3T6 cells to mitogenic signals.
摘要
在从营养培养基中去除血清后，小鼠成纤维细胞培养物中通过碱基交换合成磷脂酰丝氨酸和DNA合成均迅速下降。添加血清后3小时内，碱基交换恢复到对照水平，而DNA合成滞后10小时。因此，磷脂酰丝氨酸合成是3T6细胞对促有丝分裂信号的早期反应。
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