Choi Sang Zin, Choi Sang Un, Lee Kang Ro
Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Arch Pharm Res. 2005 Oct;28(10):1142-6. doi: 10.1007/BF02972976.
Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8alpha-hydroxy-11alpha, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3beta-hydroxy-8alpha-epoxymethylacriloiloxy-4(15),10(14),11(13)-trien-guaian-6,12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23-1.72 microg/mL.
通过对云木香（菊科）地上部分甲醇提取物进行色谱分离，分离出了七种倍半萜内酯。通过光谱分析确定它们的结构分别为洋蓟苦素（1）、阿尔盖林B（2）、塞贝林F（3）、8α-羟基-11α,13-二氢扎鲁扎宁C（4）、去酰基洋蓟苦素（5）、3β-羟基-8α-环氧甲基丙烯酰氧基-4(15),10(14),11(13)-三烯-愈创木烷-6,12-内酯（6）和坎达瓦诺内酯（7）。化合物1和2对五种培养的人肿瘤细胞系显示出显著的细胞毒性，ED50值范围为0.23 - 1.72微克/毫升。
