Mencoboni M, Lerza R, Bogliolo G, Flego G, Pannacciulli I
Dipartimento di Medicina Interna (DI.M.I.), Università di Genova, Italy.
In Vivo. 1992 Jan-Feb;6(1):41-4.
For a long time some pesticides (chlordane, lindane, DDT) have been associated with bone marrow aplasia. Little is known on the toxic activity of the herbicides s-triazines on hemopoiesis. We studied the effect of one of these compounds (atrazine) on mouse hemopoietic progenitors (CFU-S and GM-CFC) and on peripheral blood (leukocytes and reticulocytes) after a single i.p. injection of 58.65 mg/kg. The peripheral blood leukocyte level was not modified; on the contrary, reticulocytes dropped severely but recovered promptly. Hemopoietic progenitors were severely hit but they recovered and reached normal levels in a few days. Our results demonstrate a hemotoxic effect of atrazine. However, more data are needed, especially in experiments with chronic exposure.
长期以来，某些农药（氯丹、林丹、滴滴涕）一直与骨髓再生障碍有关。关于除草剂 s-三嗪对造血作用的毒性活性，人们了解甚少。我们研究了其中一种化合物（莠去津）在单次腹腔注射 58.65 mg/kg 后对小鼠造血祖细胞（CFU-S 和 GM-CFC）以及外周血（白细胞和网织红细胞）的影响。外周血白细胞水平未发生改变；相反，网织红细胞严重下降，但很快恢复。造血祖细胞受到严重打击，但在几天内恢复并达到正常水平。我们的结果证明了莠去津的血液毒性作用。然而，还需要更多数据，尤其是在慢性暴露实验中。
