糖生物学的大规模研究方法。

Campbell Christopher T, Yarema Kevin J

Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

Genome Biol. 2005;6(11):236. doi: 10.1186/gb-2005-6-11-236. Epub 2005 Nov 3.

Glycosylation, the attachment of carbohydrates to proteins and lipids, influences many biological processes. Despite detailed characterization of the cellular components that carry out glycosylation, a complete picture of a cell's glycoconjugates remains elusive because of the challenges inherent in characterizing complex carbohydrates. This article reviews large-scale techniques for accelerating progress in glycobiology.

糖基化，即碳水化合物与蛋白质和脂质的连接，影响着许多生物学过程。尽管对进行糖基化的细胞成分已有详细的表征，但由于在表征复杂碳水化合物方面存在固有的挑战，细胞糖缀合物的全貌仍然难以捉摸。本文综述了加速糖生物学进展的大规模技术。