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[两例绝经后女性额部纤维性脱发]

[Two cases of frontal fibrosing alopecia in postmenopausal women].

作者信息

Herrmann Anke, Bormann Gisela, Marsch Wolfgang Christian, Wohlrab Johannes

机构信息

Universitätsklinik für Dermatologie und Venerologie der Martin-Luther-Universität Halle-Wittenberg, Halle.

出版信息

J Dtsch Dermatol Ges. 2004 Aug;2(8):684-6. doi: 10.1046/j.1439-0353.2004.04772.x.

Abstract

Frontal fibrosing alopecia (FFA) is an uncommon, slowly progressive, cicatricial alopecia which mainly affects postmenopausal women. It is considered to be a variant of lichen planopilaris. We describe two postmenopausal women who developed over 11 and 24 months an asymptomatic atrophic alopecia, restricted to the frontal hairline. The diagnosis of FFA was confirmed by biopsy showing a perifollicular lymphocytic infiltrate with fibrosis. Topical corticosteroids, in one case combined with minoxidil, administered for 3 months arrested the hair loss. The treatment of FFA is often difficult. In most cases, the disease resolves spontaneously after several years. Immunomodulators such as corticosteroids and calcineurin antagonists should be tried in the early stage of FFA (frontal effluvium with perifollicular erythema) in order to arrest the disease in its inflammatory phase.

摘要

额部纤维性秃发(FFA)是一种罕见的、缓慢进展的瘢痕性秃发,主要影响绝经后女性。它被认为是扁平苔藓性毛囊病的一种变体。我们描述了两名绝经后女性,她们在11个月和24个月内出现了无症状性萎缩性秃发,局限于额发际线。FFA的诊断通过活检证实,显示毛囊周围淋巴细胞浸润伴纤维化。局部使用皮质类固醇,其中1例联合米诺地尔,治疗3个月后脱发停止。FFA的治疗通常很困难。在大多数情况下,该病会在数年后自行缓解。在FFA早期(伴有毛囊周围红斑的额部脱发)应尝试使用免疫调节剂,如皮质类固醇和钙调神经磷酸酶拮抗剂,以便在炎症期控制病情。

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