Fava Cristiano, Burri Philippe, Almgren Peter, Arcaro Guido, Groop Leif, Lennart Hulthén U, Melander Olle
Department of Endocrinology, University Hospital MAS, Malmö, Sweden.
Am J Hypertens. 2005 Nov;18(11):1402-7. doi: 10.1016/j.amjhyper.2005.05.011.
Blunted nocturnal blood pressure dipping (NBPD) as well as high variability in blood pressure (BPV) and low variability in heart rate (HRV), are associated with increased cardiovascular morbidity and mortality. The aim of this study was to determine whether these traits are heritable.
We studied 260 healthy siblings without antihypertensive drugs from 118 Swedish families. The BPV and HRV were defined as the standard deviation of BP and heart rate values recorded during 24 h, daytime (6 am to 10 pm), and night-time (10 pm to 6 am). The NBPD was defined as the ratio between night-time and daytime BP. Heritability was estimated with a maximal likelihood method implemented in the Solar software package with and without adjustment for significant covariates.
At night, significant heritability was found for systolic (33%, P < .05), diastolic (36%, P < .05), and mean (42%, P < .01) BPV. After covariate adjustment the corresponding heritability values were 23% (P = .08), 29% (P < .05), and 37% (P < .05). Daytime BPV was not heritable. The heritability of NBPD was 38% (P < .05) for systolic, 9% (P = .29) for diastolic, and 36% (P < .05) for mean BP, but after adjustment only systolic NBPD was significant (29%, P < .05). Heart rate was highly heritable both during daytime (57%, P < .001) and night-time (58%, P < .001), but the variability of heart rate, after adjustment, was only significant at night (37%, P < .05).
Our data suggest that BPV and HRV are partially under genetic control and that genetic loci of importance for these traits could be mapped by linkage analysis.
夜间血压下降减弱（NBPD）以及血压高变异性（BPV）和心率低变异性（HRV）与心血管疾病发病率和死亡率增加相关。本研究的目的是确定这些特征是否具有遗传性。
我们研究了来自118个瑞典家庭的260名未服用抗高血压药物的健康兄弟姐妹。BPV和HRV定义为24小时、白天（上午6点至晚上10点）和夜间（晚上10点至上午6点）记录的血压和心率值的标准差。NBPD定义为夜间与白天血压之比。使用Solar软件包中实施的最大似然法估计遗传性，有或没有对显著协变量进行调整。
夜间，收缩压（33%，P < 0.05）、舒张压（36%，P < 0.05）和平均血压（42%，P < 0.01）的BPV存在显著遗传性。协变量调整后，相应的遗传性值分别为23%（P = 0.08）、29%（P < 0.05）和37%（P < 0.05）。白天BPV不具有遗传性。收缩压的NBPD遗传性为38%（P < 0.05），舒张压为9%（P = 0.29），平均血压为36%（P < 0.05），但调整后仅收缩压NBPD显著（29%，P < 0.05）。心率在白天（57%，P < 0.001）和夜间（58%，P < 0.001）均具有高度遗传性，但调整后的心率变异性仅在夜间显著（37%，P < 0.05）。
我们的数据表明，BPV和HRV部分受遗传控制，并且这些特征的重要遗传位点可以通过连锁分析进行定位。
