Altintop Levent, Aygun Dursun, Sahin Havva, Doganay Zahide, Guven Hakan, Bek Yüksel, Akpolat Tekin
Department of Internal Medicine, Ondokuz Mayis University, School of Medicine, Samsun, Turkey.
J Intensive Care Med. 2005 Nov-Dec;20(6):346-50. doi: 10.1177/0885066605279834.
The aims of this study were to report experience in patients with organophosphate poisoning (OPP) and to discuss the potential role for hemoperfusion (HP) in the management of severe OPP. At the emergency service of a university hospital, 52 patients with acute OPP were included in this retrospective study. The patients were divided into 2 groups (Group 1, severe poisoning, n = 25; and Group 2, mild poisoning, n = 27). All patients with mild OPP survived. Seven patients (28%) of the 25 with severe OPP died. This study supports previous data documenting that HP is unnecessary in the management of mild OPP. Although there was not a control group (severe poisoning without HP treatment) in this study, experience suggests that HP can be useful in severe cases. Reports from centers having experience with severe OPP can help clarify this controversial issue. Randomized controlled (prospective) studies investigating the possible beneficial effects of HP on patient survival in patients with severe OPP with control group are needed.
本研究的目的是报告有机磷中毒（OPP）患者的治疗经验，并探讨血液灌流（HP）在重度OPP治疗中的潜在作用。在一所大学医院的急诊科，52例急性OPP患者被纳入这项回顾性研究。患者被分为两组（第1组，重度中毒，n = 25；第2组，轻度中毒，n = 27）。所有轻度OPP患者均存活。25例重度OPP患者中有7例（28%）死亡。本研究支持先前的数据，即轻度OPP治疗中无需进行血液灌流。尽管本研究中没有对照组（未接受血液灌流治疗的重度中毒患者），但经验表明血液灌流在重度病例中可能有用。有重度OPP治疗经验的中心所提供的报告有助于阐明这一有争议的问题。需要进行随机对照（前瞻性）研究，以调查血液灌流对有对照组的重度OPP患者生存可能产生的有益影响。
