Chonnam National University Hospital, Gwangju, Republic of Korea.
Clin Toxicol (Phila). 2011 Nov;49(9):828-33. doi: 10.3109/15563650.2011.617309. Epub 2011 Oct 7.
Methomyl is a widely used carbamate insecticide. It is known that mortality rate is generally low in carbamate poisoning, but fatalities from methomyl poisoning have been reported. Nevertheless, there is no reported comparative outcome of methomyl and organophosphate poisoning of comparable toxicity concerning mortality rate and mortality pattern.
This study aims to compare the mortality rate and pattern following methomyl poisoning with those after organophosphate poisoning of comparable toxicity.
A retrospective study was conducted on patients with cholinesterase inhibitor poisoning admitted to our institution. Among a diverse group of cholinesterase inhibitors, we included patients who presented after ingesting methomyl or World Health Organisation hazard Class I organophosphate compounds. Patients were divided into two groups; the methomyl group and the Class I organophosphate group.
The methomyl group consisted of 17 patients, and the Class I organophosphate group consisted of 42 patients. Seven patients (41.2%) in the methomyl group presented with cardiac arrest, while none presented with cardiac arrest in the Class I organophosphate group (p < 0.001). In the methomyl group, patients who had not experienced cardiac arrest at presentation survived to discharge from hospital. Among the seven patients who presented with cardiac arrest, three died from multiple organ dysfunction syndrome after resuscitation from cardiac arrest. In the Class I organophosphate group, four patients died from pneumonia and complicating acute respiratory distress syndrome. Therefore, the mortality rate was 17.6% in the methomyl group and 9.5% in the Class I organophosphate group (p = 0.399).
The mortality rate of methomyl poisoning was comparable to that of World Health Organisation Class I organophosphate poisoning. All died patients in the methomyl group experienced cardiac arrest, and died from multiple organ dysfunction syndrome after resuscitation from cardiac arrest.
灭多威是一种广泛使用的氨基甲酸酯类杀虫剂。已知氨基甲酸酯类中毒的死亡率通常较低，但有报道称灭多威中毒可导致死亡。然而，关于死亡率和死亡模式，尚无报道比较毒性相当的灭多威和有机磷中毒的结果。
本研究旨在比较灭多威中毒与毒性相当的有机磷中毒的死亡率和模式。
对我院收治的胆碱酯酶抑制剂中毒患者进行回顾性研究。在种类繁多的胆碱酯酶抑制剂中，我们纳入了摄入灭多威或世界卫生组织危害分类 I 有机磷化合物后就诊的患者。患者分为两组；灭多威组和 I 类有机磷组。
灭多威组有 17 例患者，I 类有机磷组有 42 例患者。7 例（41.2%）灭多威组患者出现心脏骤停，而 I 类有机磷组无一例出现心脏骤停（p < 0.001）。在灭多威组中，未出现心脏骤停的患者存活至出院。在 7 例出现心脏骤停的患者中，3 例在心脏骤停复苏后死于多器官功能障碍综合征。I 类有机磷组中，4 例死于肺炎并伴有急性呼吸窘迫综合征。因此，灭多威组的死亡率为 17.6%，I 类有机磷组为 9.5%（p = 0.399）。
灭多威中毒的死亡率与世界卫生组织 I 类有机磷中毒相当。灭多威组所有死亡患者均发生心脏骤停，心脏骤停复苏后死于多器官功能障碍综合征。
Zotero 插件