MMWR Morb Mortal Wkly Rep. 2005 Nov 11;54(44):1127-30.
Mesotherapy is a treatment involving local subcutaneous injections of minute quantities of various substances (e.g., vitamins or plant extracts) for cosmetic purposes (e.g., fat and wrinkle reduction or body contouring) or relief of musculoskeletal pain. In February 2005, the Virginia Department of Health and CDC were notified of a cluster of skin reactions unresponsive to antimicrobial therapy among patients who had been administered mesotherapy by an unlicensed practitioner in the District of Columbia (DC) area. This report 1) summarizes the subsequent investigation by CDC and state and local health departments in Virginia, Maryland, and DC, which identified prolonged skin reactions in 14 patients, and 2) provides recommendations for practices related to mesotherapy. Patients should accept medical therapy only from licensed practitioners and should not permit injection of substances that have not been approved by the Food and Drug Administration (FDA). Licensed practitioners should follow safe-injection practices when practicing mesotherapy and patients should observe that safe-injection practices are followed.
中胚层疗法是一种通过在皮下局部注射微量各种物质（如维生素或植物提取物）来达到美容目的（如减少脂肪和皱纹或塑形）或缓解肌肉骨骼疼痛的治疗方法。2005年2月，弗吉尼亚州卫生部和美国疾病控制与预防中心（CDC）接到通知，在哥伦比亚特区（DC）地区，一群接受了未经许可的从业者进行中胚层疗法的患者出现了对抗菌治疗无反应的皮肤反应。本报告1）总结了CDC以及弗吉尼亚州、马里兰州和DC的州和地方卫生部门随后进行的调查，该调查确定了14名患者出现了长期皮肤反应，2）提供了与中胚层疗法相关的操作建议。患者应仅接受有执照从业者的医疗治疗，不应允许注射未经美国食品药品监督管理局（FDA）批准的物质。有执照的从业者在进行中胚层疗法时应遵循安全注射操作规范，患者应注意观察是否遵循了安全注射操作规范。
