Placencia M, Shorvon S D, Paredes V, Bimos C, Sander J W, Suarez J, Cascante S M
Community Management of Epilepsy Project, Quito, Ecuador.
Brain. 1992 Jun;115 ( Pt 3):771-82. doi: 10.1093/brain/115.3.771.
A large-scale neuro-epidemiological study was carried out in a population of 72,121 inhabitants of a region of Northern Ecuadorian Andean Sierra, to identify prevalence and incidence rates of epileptic seizures and to identify demographic and geographic variations in these rates. Calculations were made using three datasets. First, rates were calculated from all cases identified in the field (raw dataset); secondly, lower rates were calculated based on a further diagnostic and reclassification procedure (minimum estimated dataset); thirdly, higher rates were derived by calculating false negative rates from the screening procedures, and adding these to the cases actually identified (maximum estimated dataset). Lifetime point-prevalence rates between 12.2/1000 and 19.5/1000 were recorded (minimum and maximum estimated rates), and the prevalence of active epileptic seizures was between 6.7/1000 and 8.0/1000 (minimum estimated and raw datasets). Incidence rate ranging between 122/100,000/year and 190/100,000/year were found (minimum, estimated and raw datasets). A marked difference in prevalence rates was found in two subregions of the survey area, and also in urban and rural areas. The reasons for these differences were not identified.
在厄瓜多尔安第斯山脉北部一个地区的72121名居民中开展了一项大规模神经流行病学研究，以确定癫痫发作的患病率和发病率，并确定这些发病率在人口统计学和地理方面的差异。使用三个数据集进行计算。首先，根据实地发现的所有病例计算发病率（原始数据集）；其次，基于进一步的诊断和重新分类程序计算较低的发病率（最小估计数据集）；第三，通过计算筛查程序中的假阴性率并将其加到实际发现的病例数中得出较高的发病率（最大估计数据集）。记录的终生点患病率在12.2/1000至19.5/1000之间（最小和最大估计率），活动性癫痫发作的患病率在6.7/1000至8.0/千之间（最小估计数据集和原始数据集）。发现发病率在122/100,000/年至190/100,000/年之间（最小估计数据集和原始数据集）。在调查区域的两个次区域以及城乡地区，患病率存在显著差异。未确定造成这些差异的原因。
