挥发性有机化合物及其臭氧氧化产物混合物对鼻腔的影响。
Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products.
作者信息
Laumbach Robert J, Fiedler Nancy, Gardner Carol R, Laskin Debra L, Fan Zhi-Hua, Zhang Junfeng, Weschler Charles J, Lioy Paul J, Devlin Robert B, Ohman-Strickland Pamela, Kelly-McNeil Kathie, Kipen Howard M
机构信息
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
出版信息
J Occup Environ Med. 2005 Nov;47(11):1182-9. doi: 10.1097/01.jom.0000183338.95778.f0.
OBJECTIVE
Our objective was to determine if low levels of a mixture of volatile organic compounds (VOCs) and their ozone (O3) oxidation products, similar to what might be found in "sick buildings," cause nasal irritation and inflammation under controlled exposure conditions.
METHODS
Healthy, nonsmoking women (n=130) completed 2-hour controlled exposures to VOCs, VOCs and O3, and a masked air "MA" control in random order at least 1 week apart. VOCs and O3 concentrations were approximately 25 mg/m and approximately 40 ppb, respectively. Nasal symptoms were rated before, during, and after exposure. Nasal lavage fluid was analyzed for polymorphonuclear cells, total protein, interleukin-6, and interleukin-8.
RESULTS
We found no significant differences in symptoms or markers of nasal inflammation between exposure conditions.
CONCLUSIONS
Results suggest that VOCs and their oxidation products may not cause acute nasal effects at low concentrations.
目的
我们的目的是确定低水平的挥发性有机化合物（VOCs）及其臭氧（O3）氧化产物的混合物，类似于在“病态建筑”中可能发现的情况，在受控暴露条件下是否会引起鼻腔刺激和炎症。
方法
130名健康、不吸烟的女性以随机顺序，每次间隔至少1周，分别完成了2小时对VOCs、VOCs与O3以及无气味空气“MA”对照物的受控暴露。VOCs和O3的浓度分别约为25毫克/立方米和约40 ppb。在暴露前、暴露期间和暴露后对鼻腔症状进行评分。对鼻灌洗液进行多形核细胞、总蛋白、白细胞介素-6和白细胞介素-8的分析。
结果
我们发现在不同暴露条件下，鼻腔炎症的症状或标志物没有显著差异。
结论
结果表明，VOCs及其氧化产物在低浓度时可能不会引起急性鼻腔效应。
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