Anton M, Nenutil R, Kopecný J, Rejthar A, Zaloudík J, Hausner P, Ptácková B
III. Gynek-porod. klinika LF MU, Brno-Bohunice.
Cesk Gynekol. 1992 Apr;57(2):49-55.
We studied the relation between the 5-year disease free interval and the flow cytometric DNA content in a group of 55 patients treated by radiation for squamous cell carcinoma of the uterine cervix, stages Ib-IIIb (FIGO). The diploid DNA content was associated with a better prognosis, while prognostically unfavourable tumours tended to be aneuploid. The relation was statistically significant in the whole group (p = 0.016), in stage II disease (p = 0.003) and in the subgroup formed by the combination of stages I and II (p = 0.000). In stage III we did not prove the relation. Analysis of the survival function revealed also a better prognosis of diploid tumours (p = 0.041) in the whole group. The division into clearly diploid and non-diploid tumours seems to be more suitable for evaluation (p = 0.012). The difference between the prognostically favourable and unfavourable groups is expressed more clearly. We consider the flow cytometric DNA content a perspective prognostic parameter in squamous cell carcinoma of the uterine cervix. Its significance is apparent especially in patients treated by radiotherapy, because the size of the tumour cannot be assessed reliably in these cases.
我们研究了55例FIGO分期为Ib-IIIb期的子宫颈鳞状细胞癌放疗患者的5年无病间期与流式细胞术检测的DNA含量之间的关系。二倍体DNA含量与较好的预后相关，而预后不良的肿瘤往往为非整倍体。在整个研究组中这种关系具有统计学意义（p = 0.016），在II期疾病中（p = 0.003）以及I期和II期联合组成的亚组中（p = 0.000）均有统计学意义。在III期，我们未证实这种关系。生存函数分析也显示整个研究组中二倍体肿瘤的预后较好（p = 0.041）。将肿瘤分为明确的二倍体和非二倍体似乎更适合评估（p = 0.012）。预后良好和不良组之间的差异表达得更明显。我们认为流式细胞术检测的DNA含量是子宫颈鳞状细胞癌一个有前景的预后参数。其意义尤其在接受放疗的患者中较为明显，因为在这些病例中肿瘤大小无法可靠评估。
