Luther Neal, Greenfield Jeffrey P, Chadburn Amy, Schwartz Theodore H
Department of Neurological Surgery, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA.
J Neurooncol. 2005 Nov;75(2):185-8. doi: 10.1007/s11060-005-1862-z.
Advances in immunophenotypic profiling now permit characterization of natural killer/T-cell (NK/T-cell) lymphoma as distinct from other extranodal T- and B-cell Non-Hodgkin's lymphomas. NK/T-cell lymphoma presents most commonly in the nasal cavity. Disease progression to the central nervous system (CNS) is a rare phenomenon. We present here, to our knowledge, the first immunophenotypically-confirmed case of direct extension of nasal NK/T-cell lymphoma to the brain. In addition, we review the literature with respect to NK/T-cell lymphoma metastasis to the CNS. The overall prevalence of NK/T-cell lymphoma CNS metastasis is less than 3%. Although rare, CNS invasion portends a poor prognosis, emphasizing the importance of early and accurate immunophenotype profiling and the need for novel, aggressive therapy.
免疫表型分析的进展现在使得自然杀伤/T细胞（NK/T细胞）淋巴瘤能够与其他结外T细胞和B细胞非霍奇金淋巴瘤区分开来。NK/T细胞淋巴瘤最常出现在鼻腔。疾病进展至中枢神经系统（CNS）是一种罕见现象。据我们所知，我们在此报告首例经免疫表型证实的鼻腔NK/T细胞淋巴瘤直接蔓延至脑部的病例。此外，我们回顾了关于NK/T细胞淋巴瘤转移至CNS的文献。NK/T细胞淋巴瘤CNS转移的总体发生率低于3%。尽管罕见，但CNS侵犯预示预后不良，这凸显了早期准确免疫表型分析的重要性以及对新型积极治疗的需求。
