颅中窝鼻型结外自然杀伤/T细胞淋巴瘤：一例报告
Extranodal natural killer/T cell lymphoma, nasal type in the middle cranial fossa: A case report.
作者信息
Wang Han, Xia Xiaolong, Qian Cong
机构信息
Department of Geriatrics, Tongde Hospital of Zhejiang Province, Hangzhou Department of Neurosurgery, Lanxi People's Hospital, Lanxi Department of Neurological Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
出版信息
Medicine (Baltimore). 2018 Aug;97(34):e12028. doi: 10.1097/MD.0000000000012028.
INTRODUCTION
Extranodal natural killer (NK)/T cell lymphomas, nasal type, are aggressive, non-Hodgkin lymphomas. Extranodal NK/T cell lymphomas, nasal type, involving the central nervous system (CNS) are rare; therefore, delayed diagnosis easily occurs and is associated with a poor prognosis. Early diagnosis and patented systemic chemotherapy are necessary.
CASE PRESENTATION
We present a case of 34-year-old male with facial numbness and diplopia. He was diagnosed with extranodal NK/T cell lymphoma, nasal type, involving the CNS. The tumor, located in the right middle fossa, was subtotally removed, and 3 cycles of systemic chemotherapy were given. He later died of severe neutropenia and infection.
CONCLUSION
NK/T cell lymphomas should be considered to be a potential cause of facial numbness and diplopia. A L-asparaginase-based regimen resulted in reasonable tumor suppression, but adverse effects, including fatal neutropenia, should be carefully considered.
引言
结外自然杀伤（NK）/T细胞淋巴瘤，鼻型，是侵袭性非霍奇金淋巴瘤。结外NK/T细胞淋巴瘤，鼻型，累及中枢神经系统（CNS）很罕见；因此，容易出现诊断延迟且预后较差。早期诊断和有效的全身化疗很有必要。
病例报告
我们报告一例34岁男性，有面部麻木和复视症状。他被诊断为结外NK/T细胞淋巴瘤，鼻型，累及中枢神经系统。肿瘤位于右侧中颅窝，行次全切除，并给予3个周期的全身化疗。他后来死于严重中性粒细胞减少和感染。
结论
NK/T细胞淋巴瘤应被视为面部麻木和复视的潜在病因。基于左旋门冬酰胺酶的方案可实现合理的肿瘤抑制，但包括致命性中性粒细胞减少在内的不良反应应予以谨慎考虑。
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