Chlumská A, Velenská Z, Vítková I, Plavka R
II. patologicko-anatomický ústav 1. LF UK Praha.
Cesk Patol. 1992 May;28(2):113-7.
Liver cholestasis was found in 50 autopsies (23 per cent) among 221 neonates and infants who died in intensive care units. It developed from the 4th postnatal day, was mostly mild and present in biliary capillaries as well as in small interlobular biliary ducts, later there was found phagocytosis of biliary pigment by Kupffer cells. In protracted jaundice there was an irregular increase of small cholangioles derivable from a ductal transformation of periportal hepatocytes. Bile ducts proliferation was connected with a slight widening of portal tracts in infants surviving until the 6th and 8th week. The cause of cholestatic liver lesion remained obscure.
在重症监护病房死亡的221例新生儿和婴儿的尸检中，发现50例（23%）存在肝内胆汁淤积。胆汁淤积从出生后第4天开始出现，大多为轻度，存在于胆小管及小叶间小胆管内，随后可见库普弗细胞吞噬胆色素。在持续性黄疸中，可发现由门周肝细胞的导管样化生而来的小胆管不规则增生。在存活至第6周和第8周的婴儿中，胆管增生与门管区轻度增宽有关。胆汁淤积性肝损害的病因仍不清楚。
