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Critical role of ITIM-bearing FcgammaR on DCs in the capture and presentation of native antigen to B cells.

作者信息

Dubois Bertrand, Caux Christophe

机构信息

INSERM U404 "Immunité et Vaccination", IFR-128 Biosciences Lyon Gerland, 21 avenue Tony Garnier, 69365 Lyon Cedex 07, France.

出版信息

Immunity. 2005 Nov;23(5):463-4. doi: 10.1016/j.immuni.2005.10.005.

DOI:10.1016/j.immuni.2005.10.005
PMID:16286014
Abstract

The contribution of dendritic cells (DCs) to antibody responses through antigen-unspecific B cell costimulation is well documented. now demonstrate that the ITIM-bearing FcgammaRIIB allows DCs to recycle internalized native antigen (Ag) for presentation to B cells, a process that might be critical for the initiation of humoral responses.

摘要

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Critical role of ITIM-bearing FcgammaR on DCs in the capture and presentation of native antigen to B cells.
Immunity. 2005 Nov;23(5):463-4. doi: 10.1016/j.immuni.2005.10.005.
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