Lee Jong In, Kim Jong Hyun, Kim Hye Won, Choi Eun Suk, Lim Seong Hoon, Ko Young Jin, Han Young Min
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Korea.
Brain Inj. 2005 Dec 20;19(14):1207-11. doi: 10.1080/02699050500309338.
To evaluate the process of bone metabolism after traumatic brain injury.
Randomized controlled trial.
Rats were randomly assigned to either the brain injury group or to the sham-operation group using a fluid percussion device. The BMDs of lumbar vertebrae and proximal femur and bone turnover markers, osteocalcin and carboxy-terminal telopeptide, were measured at three points: the day before surgery and 1 and 3 weeks post-operatively. The biomechanics (maximum load of tibia and femoral neck) were measured 3 weeks post-operatively.
There was significant change in the BMDs of lumbar vertebrae 1 week post-operatively and of both distal femurs 3 weeks post-operatively (p < 0.05). A significant change in the maximum load of femoral neck was also observed 3 weeks post-operatively between the brain injury and the sham-operation groups (p = 0.044).
This finding suggests that brain injury could induce osteoporosis by immobilization.
