Department of Rehabilitation Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
J Korean Med Sci. 2010 Jun;25(6):938-44. doi: 10.3346/jkms.2010.25.6.938. Epub 2010 May 25.
We evaluated the efficacy of oral alendronate with different dosing regimens for non-nociceptive symptoms and osteoporosis in a sciatic nerve chronic constriction injury (CCI) model. Male Sprague-Dawley rats (n=60) were subdivided into sham control (SC) group and CCI groups, which were divided according to dosage and time of oral alendronate administration: no treatment (NT), low dosage early (LE), high dosage early (HE), low dosage late (LL) and high dosage late (HL). We measured the thickness and temperature of the hind paw, bone mineral density (BMD) of the tibia, along with tibia bone strength. On the 14th day post-CCI, the HE group showed significant reduction in thickness and temperature (P<0.001). On the 42nd day post-CCI, the HE group showed significant reduction in temperature compared to the NT group (P<0.001). Also, both HE and HL groups showed statistically significant increased tibia BMD (P<0.001), along with increase of tibia bone strength compared to the NT group. Based on these findings, early alendronate in high dosages is effective in the non-nociceptive symptoms; early and late alendronate in high dosages, are effective in preventing bone dystrophic changes in a CCI model.
我们评估了不同剂量的口服阿仑膦酸钠治疗坐骨神经慢性缩窄性损伤（CCI）模型中非伤害性症状和骨质疏松症的疗效。雄性 Sprague-Dawley 大鼠（n=60）分为假手术对照（SC）组和 CCI 组，CCI 组根据口服阿仑膦酸钠的剂量和时间进一步分为：未治疗（NT）组、早期低剂量（LE）组、早期高剂量（HE）组、晚期低剂量（LL）组和晚期高剂量（HL）组。我们测量了后爪的厚度和温度、胫骨的骨矿物质密度（BMD）和胫骨骨强度。在 CCI 后第 14 天，HE 组的厚度和温度明显降低（P<0.001）。在 CCI 后第 42 天，与 NT 组相比，HE 组的温度明显降低（P<0.001）。此外，HE 和 HL 组的胫骨 BMD 均明显高于 NT 组（P<0.001），胫骨骨强度也明显高于 NT 组。基于这些发现，早期高剂量的阿仑膦酸钠对非伤害性症状有效；早期和晚期高剂量的阿仑膦酸钠对 CCI 模型中的骨营养不良变化均有效。
