耐力型业余运动员体内维生素B12状态的改变

Altered vitamin B12 status in recreational endurance athletes.

作者信息

Herrmann Markus, Obeid Rima, Scharhag Juergen, Kindermann Wilfried, Herrmann Wolfgang

机构信息

University Hospital of Saarland, Dept. of Clinical Chemistry and Laboratory Medicine, Homburg/Saar, Germany.

出版信息

Int J Sport Nutr Exerc Metab. 2005 Aug;15(4):433-41. doi: 10.1123/ijsnem.15.4.433.

DOI:10.1123/ijsnem.15.4.433

PMID:16286674

Abstract

This study aimed to compare the vitamin B(12)and folate status of recreational endurance athletes and inactive controls by modern biomarkers. In 72 athletes (38 +/- 7 y) and 46 inactive controls (38 +/- 9 y) serum levels of vitamin B(2), methylmalonic acid (MMA), holotranscobalamin II (holoTC), folate, and homocysteine (Hcy) were measured. Vitamin B(12)and folate levels of both groups were comparable, but athletes had higher median (25.-75. percentile) MMA [242 (196 to 324) versus 175 (141 to 266) nmol/L] and holoTC concentrations [67 (52 to 93) versus 55 (45 to 70) pmol/L] than controls. Hcy was slightly lower in athletes [9.2 (7.2 to 12.6) versus 10.8 (8.9 to 12.9) nmol/L]. In controls, we found the following correlations: vitamin B(12)and MMA (r = -0.38), vitamin B(12)and holoTC (r = 0.51), MMA and holoTC (r = -0.36). In athletes, MMA did not correlate with vitamin B(12)and holoTC. Our data suggests an altered vitamin B(12)metabolism in recreational athletes that needs further investigation.

摘要

本研究旨在通过现代生物标志物比较业余耐力运动员和不运动对照组的维生素B12和叶酸水平。对72名运动员（38±7岁）和46名不运动对照组（38±9岁）测量了血清维生素B2、甲基丙二酸（MMA）、全转钴胺素II（holoTC）、叶酸和同型半胱氨酸（Hcy）水平。两组的维生素B12和叶酸水平相当，但运动员的MMA中位数（第25-75百分位数）[242（196至324）对175（141至266）nmol/L]和holoTC浓度[67（52至93）对55（45至70）pmol/L]高于对照组。运动员的Hcy略低[9.2（7.2至12.6）对10.8（8.9至12.9）nmol/L]。在对照组中，我们发现以下相关性：维生素B12与MMA（r = -0.38）、维生素B12与holoTC（r = 0.51）、MMA与holoTC（r = -0.36）。在运动员中，MMA与维生素B12和holoTC不相关。我们的数据表明业余运动员的维生素B12代谢发生了改变，需要进一步研究。