Shimizu H, Uehara Y, Negishi M, Shimomura Y, Takahashi M, Fukatsu A, Takahashi S, Tanaka Y, Kashima K, Kobayashi I
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Exp Clin Endocrinol. 1992;99(1):45-8. doi: 10.1055/s-0029-1211131.
Changes in hypothalamic monoamine metabolism were investigated in the genetically obese yellow (Ay/a) mouse. At the age of 6 weeks when there was no difference in body weight between black (a/a) and yellow (Ay/a) mice, the contents of norepinephrine (NE), dopamine (DA) and their main metabolites (MHPG, DOPAC) were already significantly reduced in yellow (Ay/a) mice. Reduction of 5-hydroxytryptamine (5-HT) level and an increasing 5-HIAA/5-HT ratio has been observed. When a significant increase in body weight in the yellow (Ay/a) mouse at the age of 12 weeks was present, both NE and DA contents have been increased in the hypothalamus of the obese mouse. MHPG level was lower than in the lean mouse, resulting in an increase of MHPG/NE ratio. The present study suggests that the observed reduction in hypothalamic NE and DA metabolism might be involved in the development of overweight gain in the yellow (Ay/a) mouse.
对遗传性肥胖的黄色（Ay/a）小鼠的下丘脑单胺代谢变化进行了研究。在6周龄时，黑色（a/a）小鼠和黄色（Ay/a）小鼠的体重没有差异，但黄色（Ay/a）小鼠中去甲肾上腺素（NE）、多巴胺（DA）及其主要代谢产物（MHPG、DOPAC）的含量已经显著降低。已观察到5-羟色胺（5-HT）水平降低，5-羟吲哚乙酸/5-羟色胺（5-HIAA/5-HT）比值升高。当12周龄的黄色（Ay/a）小鼠体重显著增加时，肥胖小鼠下丘脑的NE和DA含量均增加。MHPG水平低于瘦小鼠，导致MHPG/NE比值升高。本研究表明，观察到的下丘脑NE和DA代谢降低可能与黄色（Ay/a）小鼠体重增加的发生有关。
