Jackson E, Stolz D, Martin R
Horm Metab Res. 1976 Nov;8(6):452-5. doi: 10.1055/s-0028-1093612.
It has been reported that the adrenal gland is essential to the development of obesity if Ay/a Yellow obese mice (Hausberger and Hausberger 1960). Since the actual body composition data to support this report has not been published, we attempted to duplicate this observation by adrenalectomy of the Yellow mice before the onset of obesity. Two groups of Yellow mice (Ay/a) and normal mice (a/a) were either sham operated or adrenalectomized at two months of age and at four months of age. Body weight was monitored until body gain had stopped. At that time the animals were sacrified and checked for completeness of adrenal removal. Body composition of dry matter, fat, protein, and ash was determined. Adrenalectomy caused a reduction of body fat of 33% and 30% in both the a/a Control and the Ay/a Yellow mice, respectively. The adrenalectomized Yellow mice were still fatter than adrenalectomized Controls (25.3% fat vs. 10.6% fat). Yellow and control adrenalectomized mice showed similar depression in growth rate. These data suggest that while the adrenal gland is essential for complete expression of the genetic potential for fat deposition, it may not be necessary for partial expression indicating a secondary role in the development of obesity in the Ay/a Yellow mouse.
据报道，如果Ay/a黄色肥胖小鼠（豪斯伯格和豪斯伯格，1960年），肾上腺对肥胖的发展至关重要。由于尚未发表支持该报告的实际身体成分数据，我们试图通过在肥胖开始前对黄色小鼠进行肾上腺切除术来重复这一观察结果。两组黄色小鼠（Ay/a）和正常小鼠（a/a）在两个月龄和四个月龄时分别进行假手术或肾上腺切除术。监测体重直至体重增加停止。此时处死动物并检查肾上腺切除是否彻底。测定干物质、脂肪、蛋白质和灰分的身体成分。肾上腺切除术分别使a/a对照组和Ay/a黄色小鼠的体脂减少了33%和30%。肾上腺切除的黄色小鼠仍然比肾上腺切除的对照组更胖（脂肪含量分别为25.3%和10.6%）。黄色和对照肾上腺切除小鼠的生长速率表现出相似的下降。这些数据表明，虽然肾上腺对于脂肪沉积遗传潜力的完全表达至关重要，但对于部分表达可能并非必要，这表明肾上腺在Ay/a黄色小鼠肥胖发展中起次要作用。
