Haugeberg Glenn, Emery Paul
Department of Rheumatology, Sørlandet Hospital, Kristiansand, Norway.
Rheum Dis Clin North Am. 2005 Nov;31(4):715-28. doi: 10.1016/j.rdc.2005.07.013.
New research has revealed common pathophysiologic and cellular mechanisms behind the development of osteoporosis and joint damage in rheumatoid arthritis (RA). Because osteoporosis is a direct consequence of the inflammatory disease process, bone mass measurements in principle could be an outcome marker of inflammation, of damage, and of response to therapeutic intervention. Several devices have been developed for quantitative bone mass assessment including dual energy x-ray absorptiometry (DXA), which is considered the reference standard. This article based on current data and understanding discusses the use of DXA as a diagnostic and assessment tool especially in early RA.
新研究揭示了类风湿关节炎（RA）中骨质疏松和关节损伤发生背后的常见病理生理及细胞机制。由于骨质疏松是炎症性疾病过程的直接后果，原则上骨量测量可以作为炎症、损伤及治疗干预反应的一个结果标志物。已经开发了多种用于定量骨量评估的设备，包括双能X线吸收法（DXA），它被视为参考标准。本文基于当前数据和认识，讨论了DXA作为诊断和评估工具的应用，尤其是在早期RA中的应用。
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