Newman Anne B, Foster Greg, Givelber Rachel, Nieto F Javier, Redline Susan, Young Terry
Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Arch Intern Med. 2005 Nov 14;165(20):2408-13. doi: 10.1001/archinte.165.20.2408.
The relationship of weight changes to the incidence, progression, and remission of sleep-disordered breathing (SDB) is not well defined. This study aims to determine the relationship between change in weight and progression or remission of SDB by polysomnography.
We performed a longitudinal cohort study of the cardiovascular consequences of sleep apnea in diverse US communities. Sleep apnea and polysomnographic indicators of SDB were assessed 5 years apart.
A total of 2968 men and women (mean age, 62 years) participated in the study. Men were more likely to have an increase in Respiratory Disturbance Index (RDI) with a given increase in weight than were women, and this was not explained by differences in starting weight, waist circumference, age, or ethnicity. In a linear regression analysis, both men and women had a greater increase in RDI with weight gain than a decrease in RDI with weight loss. In a categorical analysis of larger degrees of change, this sex difference was also evident. Associations were similar in diverse ethnic groups. However, SDB progressed over time, even in those with stable weight.
Modest changes in weight were related to an increase or decrease in SDB, and this association was stronger in men than in women.
体重变化与睡眠呼吸障碍（SDB）的发生率、进展及缓解之间的关系尚未明确。本研究旨在通过多导睡眠图确定体重变化与SDB进展或缓解之间的关系。
我们对美国不同社区睡眠呼吸暂停的心血管后果进行了一项纵向队列研究。相隔5年评估睡眠呼吸暂停及SDB的多导睡眠图指标。
共有2968名男性和女性（平均年龄62岁）参与了该研究。在体重增加相同的情况下，男性比女性更有可能出现呼吸紊乱指数（RDI）升高，且起始体重、腰围、年龄或种族差异无法解释这一现象。在线性回归分析中，男性和女性体重增加时RDI的升高幅度均大于体重减轻时RDI的降低幅度。在对更大程度变化的分类分析中，这种性别差异也很明显。不同种族群体中的关联相似。然而，即使体重稳定，SDB也会随时间进展。
体重的适度变化与SDB的增加或减少有关，且这种关联在男性中比在女性中更强。
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