Jones C T, Luther E, Ritchie J W, Worthington D
Endocrinology. 1975 Jan;96(1):231-4. doi: 10.1210/endo-96-1-231.
The disappearance of 125-I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than maternal arterial plasma ACTH concentration has been ascribed to a higher rate of secretion rather than a reduced rate of clearance compared with the ewe. There was no evidence of placental transfer of immunologically reactive ACTH.
在向孕羊或胎儿单次注射后，追踪了125-I-促肾上腺皮质激素（ACTH）在4只孕羊及其胎儿循环中的消失情况。胎儿和孕羊的平均代谢清除率分别为55和34毫升/分钟/千克，两者的半衰期均约为1分钟。胎儿动脉血浆促肾上腺皮质激素浓度高于母体，这归因于其分泌速率较高，而非与孕羊相比清除速率降低。没有证据表明具有免疫反应性的促肾上腺皮质激素可通过胎盘转运。
