Collins D C, Graham C E, Preedy J R
Endocrinology. 1975 Jan;96(1):93-101. doi: 10.1210/endo-96-1-93.
Urinary estrone, estradiol-17beta, estriol, pregnanediol and androsterone were identified and measured during 3 menstrual cycles in 2 female orangutans. In 2 of the cycles, the animals excreted 1-8 mug/day estrone, 0.5-6 mug/day estradiol-17beta, 1-8 mug/day estriol, 20-206 mug/day pregnanediol and 120-522 mug/day androsterone during the first half of the menstrual cycle. In the second half of the cycle, corresponding values were 3-21 mug/day estrone, 2-10 mug/day estradiol-17beta, 1-9 mug/day estriol, 54-800 mug/day pregnanediol and 90-1158 mug/day androsterone. In 1 cycle, the estrogen values for the second half were considerably higher, possibly due to the animal becoming pregnant just before this study commenced. The values for estrone and estradiol-17beta are similar to those found in the human and chimpanzee menstrual cycle. The values for estriol were lower than in the human but higher than in the chimpanzee. Levels for urinary pregnanediol and androsterone were significantly lower than in the human. Variations during the menstrual cycle for estrone were characterized by a midcycle peak followed by a second peak in the luteal phase. No definite pattern was apparent for estradiol-17beta or estriol. Both urinary pregnanediol and androsterone levels were low during the first half of the cycle, started to rise just after midcycle, and showed a peak during the second half of the menstrual cycle.
在2只雌性猩猩的3个月经周期中，对尿中的雌酮、雌二醇 - 17β、雌三醇、孕二醇和雄酮进行了鉴定和测量。在其中2个周期中，动物在月经周期的前半期每天排泄1 - 8微克雌酮、0.5 - 6微克雌二醇 - 17β、1 - 8微克雌三醇、20 - 206微克孕二醇和120 - 522微克雄酮。在周期的后半期，相应的值分别为3 - 21微克/天雌酮、2 - 10微克/天雌二醇 - 17β、1 - 9微克/天雌三醇、54 - 800微克/天孕二醇和90 - 1158微克/天雄酮。在1个周期中，后半期的雌激素值显著更高，可能是因为该动物在本研究开始前刚刚怀孕。雌酮和雌二醇 - 17β的值与人类和黑猩猩月经周期中的值相似。雌三醇的值低于人类但高于黑猩猩。尿中孕二醇和雄酮的水平显著低于人类。月经周期中雌酮的变化特点是在周期中期出现一个峰值，随后在黄体期出现第二个峰值。雌二醇 - 17β或雌三醇没有明显的确定模式。尿中孕二醇和雄酮水平在周期的前半期较低，在周期中期过后开始上升，并在月经周期的后半期出现峰值。
