Février Florence C, Smith Emilie D, Comins Daniel L
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA.
Org Lett. 2005 Nov 24;7(24):5457-60. doi: 10.1021/ol052196j.
[reaction: see text] Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields. These methodologies allow the direct introduction of a plethora of functional groups onto the pyridine ring of nicotine.
[反应：见正文] 在吡啶环的C-2和C-6位对（S）-尼古丁及其衍生物进行区域选择性去质子化反应，产率良好至优异。这些方法允许在尼古丁的吡啶环上直接引入大量官能团。
