雌性生殖组织中钙结合蛋白-D9k的生物学与生理学：类固醇和内分泌干扰物的影响
Biology and physiology of Calbindin-D9k in female reproductive tissues: involvement of steroids and endocrine disruptors.
作者信息
Choi Kyung-Chul, Leung Peter C K, Jeung Eui-Bae
机构信息
Department of Obstetrics and Gynecology, British Columbia Children's and Women's Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, BC V6H 3V5, Canada.
出版信息
Reprod Biol Endocrinol. 2005 Nov 16;3:66. doi: 10.1186/1477-7827-3-66.
Abstract
Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity related with intracellular calcium level and is not under the control of vitamin D despite the presence of vitamin D receptors. But, it is under the control of the sex steroid hormones, estrogen (E2) and progesterone (P4), in female reproductive systems including the uterus and placenta. Thus, in this review, we summarize recent research literature in regards to the expression and regulation of CaBP-9k in mammals and introduce the research data of recent studies by us and others.
摘要
尽管钙结合蛋白-D9k（CaBP-9k）是一种具有钙结合位点的胞质钙结合蛋白，在多种组织如肠道、子宫和胎盘中表达，但其基因及其蛋白的潜在作用尚未完全明确。子宫CaBP-9k可能参与调控与细胞内钙水平相关的子宫肌层活动，尽管存在维生素D受体，但它不受维生素D的控制。然而，在包括子宫和胎盘在内的女性生殖系统中，它受性甾体激素雌激素（E2）和孕酮（P4）的控制。因此，在本综述中，我们总结了关于哺乳动物中CaBP-9k表达和调控的最新研究文献，并介绍了我们和其他研究人员近期研究的数据。
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本文引用的文献
1
Maternal exposure to bisphenol a during late pregnancy resulted in an increase of Calbindin-D9k mRNA and protein in maternal and postnatal rat uteri.
J Reprod Dev. 2005 Aug;51(4):499-508. doi: 10.1262/jrd.17012. Epub 2005 Jun 10.
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Novel progestogenic activity of environmental endocrine disruptors in the upregulation of calbindin-D9k in an immature mouse model.
Toxicol Sci. 2005 Jan;83(1):78-88. doi: 10.1093/toxsci/kfi015. Epub 2004 Oct 27.
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Effect of genistein as a selective estrogen receptor beta agonist on the expression of Calbindin-D9k in the uterus of immature rats.
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J Reprod Dev. 2004 Aug;50(4):445-53. doi: 10.1262/jrd.50.445.
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Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat model.
Reprod Toxicol. 2004 Jul;18(5):661-8. doi: 10.1016/j.reprotox.2004.03.005.
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