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用于研究环境污染物对母婴界面影响的生物学工具。

Biological Tools to Study the Effects of Environmental Contaminants at the Feto-Maternal Interface.

作者信息

Mannelli Chiara, Ietta Francesca, Avanzati Anna Maria, Skarzynski Dariusz, Paulesu Luana

机构信息

Department of Life Sciences, University of Siena, Siena, Italy; Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Department of Life Sciences, University of Siena, Siena, Italy.

出版信息

Dose Response. 2015 Nov 12;13(4):1559325815611902. doi: 10.1177/1559325815611902. eCollection 2015 Oct-Dec.

DOI:10.1177/1559325815611902
PMID:26740808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4679191/
Abstract

The identification of reproductive toxicants is a major scientific challenge for human health. Prenatal life is the most vulnerable and important time span of human development. For obvious ethical reasons, in vivo models cannot be used in human pregnancy, and animal models do not perfectly reflect human physiology. This review describes the in vitro test models representative of the human feto-maternal interface and the effects of environmental chemicals with estrogen-like activity, mainly bisphenol A and para-nonylphenol, with a particular emphasis on the effects at low, nontoxic doses similar to concentrations commonly detected in the population.

摘要

生殖毒物的鉴定是人类健康面临的一项重大科学挑战。孕期是人类发育中最脆弱且最重要的时间段。出于明显的伦理原因，体内模型不能用于人类妊娠研究，而动物模型也无法完美反映人类生理状况。本综述描述了代表人类胎儿 - 母体界面的体外测试模型，以及具有雌激素样活性的环境化学物质的影响，主要是双酚A和对壬基酚，特别强调了在低剂量、无毒剂量下的影响，这些剂量类似于人群中常见的检测浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/68ac8219e2b3/10.1177_1559325815611902-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/f5a2af0f35e6/10.1177_1559325815611902-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/b44389fab2c8/10.1177_1559325815611902-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/0921f87f4b09/10.1177_1559325815611902-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/42b49f9fa41e/10.1177_1559325815611902-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/68ac8219e2b3/10.1177_1559325815611902-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/f5a2af0f35e6/10.1177_1559325815611902-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/b44389fab2c8/10.1177_1559325815611902-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/0921f87f4b09/10.1177_1559325815611902-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/42b49f9fa41e/10.1177_1559325815611902-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed88/4679191/68ac8219e2b3/10.1177_1559325815611902-fig5.jpg

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Bisphenol A modulates receptivity and secretory function of human decidual cells: an in vitro study.双酚A对人蜕膜细胞的接受性和分泌功能的调节作用：一项体外研究
Reproduction. 2015 Aug;150(2):115-25. doi: 10.1530/REP-14-0601. Epub 2015 May 28.
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Bisphenol A alters β-hCG and MIF release by human placenta: an in vitro study to understand the role of endometrial cells.
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