Iacobellis Gianluca, Kemp Walter
Int J Cardiol. 2006 Sep 10;112(1):116-8. doi: 10.1016/j.ijcard.2005.08.052. Epub 2005 Nov 14.
Cocaine abuse can cause degenerative and inflammatory alterations of the myocardium. Cocaine-induced myocarditis has been previously described, but mostly in chronic cocaine addicts. Among several pathogenetic mechanisms of cocaine-related myocardial damage, the myocardial adrenergic stress and cardiomyocytes apoptosis have been recently proposed. We report an unusual case of myocarditis involving the bundle of His and left bundle branch and cardiac myocytes apoptosis in otherwise healthy occasional cocaine abuser.
可卡因滥用可导致心肌的退行性和炎症性改变。此前已有可卡因诱发心肌炎的相关描述，但大多发生在慢性可卡因成瘾者中。在可卡因相关心肌损伤的几种发病机制中，心肌肾上腺素能应激和心肌细胞凋亡最近被提出。我们报告了一例罕见的心肌炎病例，累及希氏束和左束支，并伴有心肌细胞凋亡，患者为偶尔滥用可卡因的健康个体。
