Wang J, Li Q, Dong W, Chen J
Fundamental Medical Department, Nanjing Railway Medical College, China.
Hear Res. 1992 Apr;59(1):31-8. doi: 10.1016/0378-5955(92)90099-9.
Changes in endocochlear potentials (EP), cochlear microphonics (CM), and compound action potentials (CAP) with noise exposure were investigated in guinea pigs. The animals were anesthetized and immobilized and exposed to white noise at intensities ranging from 105 to 125 dB. The negative EP (N-EP) was induced by anoxia and was investigated during and after noise exposure. It was found that the general EP (G-EP, the sum of both positive EP (P-EP) and N-EP) increased remarkably during exposure to 115 dB noise but decreased during exposure to 125 dB noise. A smaller absolute value of N-EP was encountered only during exposure to 125 dB noise. The results shed light on the relationship between EP and CM, CAP changes, and the potential mechanism of EP change and its significance in noise-induced hearing loss.
研究了豚鼠噪声暴露后内耳蜗电位（EP）、耳蜗微音器电位（CM）和复合动作电位（CAP）的变化。动物麻醉并固定后，暴露于强度范围为105至125分贝的白噪声中。负EP（N-EP）由缺氧诱导，并在噪声暴露期间及之后进行研究。结果发现，一般EP（G-EP，正EP（P-EP）与N-EP之和）在暴露于115分贝噪声期间显著增加，但在暴露于125分贝噪声期间降低。仅在暴露于125分贝噪声期间观察到N-EP的绝对值较小。这些结果揭示了EP与CM、CAP变化之间的关系，以及EP变化的潜在机制及其在噪声性听力损失中的意义。
