Corsini Alberto, Bellosta Stefano, Davidson Michael H
Department of Pharmacological Sciences, University of Milan, Milan, Italy.
Am J Cardiol. 2005 Nov 7;96(9A):44K-49K; discussion 34K-35K. doi: 10.1016/j.amjcard.2005.08.007. Epub 2005 Oct 21.
Concomitant use of a fibrate and a statin may offer a therapeutic advantage to patients with dyslipidemia, especially in patients whose low-density lipoprotein cholesterol is controlled by statins but whose high-density lipoprotein cholesterol or triglycerides, or both, are not within goal. However, concern about drug-drug interactions may preclude optimal use of combination statin-fibrate therapy. This article reviews the pharmacokinetics between statins and fibrates, addressing risks associated with drug-drug interactions and combination therapy.
贝特类药物与他汀类药物联合使用可能为血脂异常患者带来治疗优势，尤其是对于那些低密度脂蛋白胆固醇已通过他汀类药物得到控制，但高密度脂蛋白胆固醇或甘油三酯，或两者均未达标的患者。然而，对药物相互作用的担忧可能会妨碍他汀类药物与贝特类药物联合治疗的最佳应用。本文综述了他汀类药物与贝特类药物之间的药代动力学，探讨了与药物相互作用及联合治疗相关的风险。
