Davies Warren R, Siu William H L, Jack Ralph W, Wu Rudolf S S, Lam Paul K S, Nugegoda Dayanthi
Department of Biotechnology and Environmental Biology, RMIT University, Melbourne, Victoria, Australia.
Mar Pollut Bull. 2005;51(8-12):1026-33. doi: 10.1016/j.marpolbul.2005.01.008.
Nodularia spumigena periodically proliferates to cause toxic algal blooms with some aquatic animals enduring and consuming high densities of the blue green algae or toxic lysis. N. spumigena contains toxic compounds such as nodularin and lipopolysaccharides. This current work investigates physiological effects of exposure from bloom conditions of N. spumigena cells and a post-bloom lysis. Biochemical and antioxidative biomarkers were comparatively studied over an acute 3-day exposure. In general, a post-bloom N. spumigena lysis caused opposite physiological responses to bloom densities of N. spumigena. Specifically, increases in glutathione (GSH) and glutathione peroxidase (GPx) and decreases in glutathione S-transferase (GST) were observed from the N. spumigena lysis. In contrast, N. spumigena cell densities decreased GSH and increased GST and lipid peroxidation (LPO) in mussels. Findings also suggest that at different stages of a toxic bloom, exposure may result in toxic stress to specific organs in the mussel.
泡沫节球藻会周期性增殖，引发有毒藻华，一些水生动物会忍受并摄食高密度的蓝藻或经历有毒裂解。泡沫节球藻含有诸如节球藻毒素和脂多糖等有毒化合物。当前这项研究调查了暴露于泡沫节球藻细胞藻华条件及藻华后裂解所产生的生理影响。在为期3天的急性暴露期间，对生化和抗氧化生物标志物进行了比较研究。总体而言，泡沫节球藻藻华后的裂解对泡沫节球藻藻华密度产生了相反的生理反应。具体而言，在泡沫节球藻裂解过程中，观察到谷胱甘肽（GSH）和谷胱甘肽过氧化物酶（GPx）增加，而谷胱甘肽S-转移酶（GST）减少。相比之下，泡沫节球藻细胞密度会使贻贝中的GSH减少，GST和脂质过氧化（LPO）增加。研究结果还表明，在有毒藻华的不同阶段，暴露可能会对贻贝的特定器官造成毒性应激。
