McMackin Craig J, Vita Joseph A
Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Methods Enzymol. 2005;396:541-53. doi: 10.1016/S0076-6879(05)96046-1.
There currently is great interest in translating findings about the importance of nitric oxide (NO) in vascular biology to the clinical arena. The bioactivity of endothelium-derived NO can readily be assessed in human subjects as vasodilation of conduit arteries or increased flow, which reflects vasodilation of resistance vessels. This chapter provides an update on the available noninvasive methodology to assess endothelium-dependent vasodilation in human subjects.
目前,人们对将一氧化氮(NO)在血管生物学中的重要性研究成果应用于临床领域有着浓厚的兴趣。内皮源性NO的生物活性可以在人体受试者中通过评估传导动脉的血管舒张或血流量增加来轻易测定,这反映了阻力血管的血管舒张情况。本章提供了关于评估人体受试者内皮依赖性血管舒张的现有非侵入性方法的最新信息。