Doctor of Physical Therapy Program, College of Health Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.
Clinical Applied Physiology Laboratory, College of Health Sciences, The University of Texas at El Paso, El Paso, TX 79902, USA.
Int J Environ Res Public Health. 2021 Oct 30;18(21):11444. doi: 10.3390/ijerph182111444.
A randomized, double-blind, placebo-controlled, cross-over study where continuous therapeutic ultrasound (CUS; at 0.4 W/cm), pulsed therapeutic ultrasound (PUS; at 20% duty cycle, 0.08 W/cm), both at 1 MHz, and placebo (equipment on, no energy provided) were randomized and applied over the forearm of the non-dominant arm for 5 min in 10 young, healthy individuals. Absolute and peak forearm blood flow (FBF) were measured via Venous Occlusion Plethysmography. FBF was measured before, halfway, and after (immediately and 5 min after) the therapeutic ultrasound (TUS) intervention. Post-ischemic peak FBF was measured 10 min before and 10 min after the TUS intervention. A two-way repeated measures ANOVA (group × time) was selected to assess differences in FBF before, during, and after TUS treatment, and for peak FBF before and after TUS treatment. FBF increased 5 min after TUS in CUS compared to placebo (2.96 ± 1.04 vs. 2.09 ± 0.63 mL/min/100 mL of tissue, < 0.05). PUS resulted in the greatest increase in Peak FBF at 10 min after US (Δ = 3.96 ± 2.02 mL/min/100 mL of tissue, = 0.06). CUS at 1 MHz was an effective treatment modality for increasing FBF up to 5 min after intervention, but PUS resulted in the greatest increase in peak FBF at 10 min after intervention.
一项随机、双盲、安慰剂对照、交叉研究中，连续治疗超声（CUS；0.4 W/cm）、脉冲治疗超声（PUS；20%占空比，0.08 W/cm），均为 1 MHz，以及安慰剂（设备开启，不提供能量）被随机应用于 10 名年轻健康个体的非优势前臂 5 分钟。绝对和峰值前臂血流量（FBF）通过静脉闭塞体积描记法进行测量。FBF 在治疗超声（TUS）干预之前、中途和之后（立即和 5 分钟后）进行测量。在 TUS 干预之前和之后 10 分钟测量缺血后峰值 FBF。选择双向重复测量方差分析（组×时间）来评估 TUS 治疗前后 FBF 的差异，以及 TUS 治疗前后峰值 FBF 的差异。与安慰剂相比，CUS 在 TUS 后 5 分钟时 FBF 增加（2.96 ± 1.04 对 2.09 ± 0.63 mL/min/100 mL 组织，<0.05）。PUS 在 US 后 10 分钟时导致峰值 FBF 的最大增加（Δ=3.96 ± 2.02 mL/min/100 mL 组织，=0.06）。1 MHz 的 CUS 是一种有效的治疗方式，可在干预后 5 分钟内增加 FBF，但 PUS 导致峰值 FBF 在干预后 10 分钟时增加最大。
