Ribeiro S C C, Santana A N C, Arriagada G H, Martins J E C, Takagaki T Y
Pulmonary Division, University of São Paulo Medical School, São Paulo, SP, Brazil.
J Infect. 2005 Nov;51(4):e195-7. doi: 10.1016/j.jinf.2005.02.020.
Aspergillus candidus, a common contaminant of grain dust, may represent an important respiratory hazard to grain workers, considering its immunomodulating capability by producing p-terphenyl metabolites and terprenins, potent cytotoxic substances. However, there are only three cases of A. candidus infection in the English literature, one fatal solitary brain mass and two onychomycosis. We describe the first case of invasive pulmonary infection and skin abscesses due to A. candidus, determination of minimal inhibitory concentration for anti-fungals, and the successful treatment with liposomal amphotericin B and itraconazole. Possible mechanisms involved in the dissemination of infection in an immunocompetent host are discussed.
白色曲霉是谷物粉尘的常见污染物，鉴于其通过产生对三联苯代谢物和萜菌素（强效细胞毒性物质）的免疫调节能力，可能对谷物工人构成重要的呼吸危害。然而，英文文献中仅有3例白色曲霉感染病例，1例为致命的孤立性脑肿块，2例为甲癣。我们描述了首例由白色曲霉引起的侵袭性肺部感染和皮肤脓肿病例，测定了抗真菌药物的最低抑菌浓度，并使用脂质体两性霉素B和伊曲康唑成功治愈。本文还讨论了在免疫功能正常宿主中感染传播可能涉及的机制。
