一名接受伏立康唑预防治疗的白血病中性粒细胞减少患者发生了对伏立康唑耐药的播散性拟青霉感染。

Voriconazole-resistant disseminated Paecilomyces variotii infection in a neutropenic patient with leukaemia on voriconazole prophylaxis.

作者信息

Chamilos Georgios, Kontoyiannis Dimitrios P

机构信息

Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

出版信息

J Infect. 2005 Nov;51(4):e225-8. doi: 10.1016/j.jinf.2005.02.005.

DOI:10.1016/j.jinf.2005.02.005

PMID:16291275

Abstract

Paecilomyces variotii, an emerging hyalohyphomycetes, has been reported to be susceptible in vitro to voriconazole. We describe a case of disseminated P. variotii infection in a neutropenic child with relapsed leukaemia who was on voriconazole prophylaxis. The P. variotii isolate was resistant to voriconazole in vitro. The patient responded to liposomal amphotericin B.

摘要

变幻青霉是一种新出现的透明丝孢霉，据报道其在体外对伏立康唑敏感。我们描述了一例患有复发性白血病的中性粒细胞减少儿童发生播散性变幻青霉感染的病例，该患儿正在接受伏立康唑预防治疗。该变幻青霉分离株在体外对伏立康唑耐药。患者对脂质体两性霉素B有反应。