采用CLSI肉汤微量稀释法测定两性霉素B、伊曲康唑、伏立康唑、泊沙康唑和卡泊芬净对20种致病性丝状真菌的最低抑菌浓度（MIC）分布及杀菌活性评估。
MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method.
作者信息
Borman Andrew M, Fraser Mark, Palmer Michael D, Szekely Adrien, Houldsworth Marian, Patterson Zoe, Johnson Elizabeth M
机构信息
Public Health England United Kingdom, Mycology Reference Laboratory, Myrtle Road, Bristol BS2 8EL, UK.
出版信息
J Fungi (Basel). 2017 May 31;3(2):27. doi: 10.3390/jof3020027.
Abstract
For filamentous fungi (moulds), species-specific interpretive breakpoints and epidemiological cut-off values (ECVs) have only been proposed for a limited number of fungal species-antifungal agent combinations, with the result that clinical breakpoints are lacking for most emerging mould pathogens. In the current study, we have compiled minimum inhibitory concentration (MIC) data for 4869 clinical mould isolates and present full MIC distributions for amphotericin B, itraconazole, voriconazole, posaconazole, and caspofungin with these isolates which comprise 20 species/genera. In addition, we present the results of an assessment of the fungicidal activity of these same five antifungal agents against a panel of 123 mould isolates comprising 16 of the same species.
摘要
对于丝状真菌（霉菌），仅针对有限数量的真菌种类与抗真菌药物组合提出了种属特异性的解释性断点和流行病学截断值（ECV），结果是大多数新兴霉菌病原体缺乏临床断点。在本研究中，我们汇总了4869株临床霉菌分离株的最低抑菌浓度（MIC）数据，并给出了两性霉素B、伊曲康唑、伏立康唑、泊沙康唑和卡泊芬净对这些包含20个种/属的分离株的完整MIC分布。此外，我们还给出了这五种抗真菌药物对一组包含16个相同种类的123株霉菌分离株的杀菌活性评估结果。
相似文献
1
MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method.采用CLSI肉汤微量稀释法测定两性霉素B、伊曲康唑、伏立康唑、泊沙康唑和卡泊芬净对20种致病性丝状真菌的最低抑菌浓度（MIC）分布及杀菌活性评估。
J Fungi (Basel). 2017 May 31;3(2):27. doi: 10.3390/jof3020027.
2
Susceptibility patterns of amphotericin B, itraconazole, posaconazole, voriconazole and caspofungin for isolates causing invasive mould infections from the SENTRY Antifungal Surveillance Program (2018-2021) and application of single-site epidemiological cutoff values to evaluate amphotericin B activity.来自哨兵抗真菌监测项目（2018 - 2021年）中引起侵袭性霉菌感染的分离株对两性霉素B、伊曲康唑、泊沙康唑、伏立康唑和卡泊芬净的药敏模式，以及应用单部位流行病学截断值评估两性霉素B的活性。
Mycoses. 2023 Oct;66(10):854-868. doi: 10.1111/myc.13620. Epub 2023 Jul 11.
3
Evaluation of antifungal susceptibility and clinical characteristics in fungal keratitis in a tertiary care center in North India.评估印度北部一家三级护理中心真菌性角膜炎的抗真菌药敏性和临床特征。
Indian J Ophthalmol. 2022 Dec;70(12):4270-4283. doi: 10.4103/ijo.IJO_855_22.
4
In vitro antifungal activities of anidulafungin and micafungin, licensed agents and the investigational triazole posaconazole as determined by NCCLS methods for 12,052 fungal isolates: review of the literature.通过美国国家临床实验室标准委员会（NCCLS）方法测定的阿尼芬净、米卡芬净（已获许可的药物）及研究性三唑类药物泊沙康唑对12052株真菌分离株的体外抗真菌活性：文献综述
Rev Iberoam Micol. 2003 Dec;20(4):121-36.
5
Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program, 2000.泊沙康唑、雷夫康唑和伏立康唑与伊曲康唑及两性霉素B相比，对239株曲霉属及其他丝状真菌临床分离株的抗真菌活性：2000年SENTRY抗菌监测项目报告
Antimicrob Agents Chemother. 2002 Apr;46(4):1032-7. doi: 10.1128/AAC.46.4.1032-1037.2002.
6
The role of epidemiological cutoff values (ECVs/ECOFFs) in antifungal susceptibility testing and interpretation for uncommon yeasts and moulds.流行病学截断值（ECV/ECOFF）在罕见酵母菌和霉菌抗真菌药敏试验及结果判读中的作用
Rev Iberoam Micol. 2016 Apr-Jun;33(2):63-75. doi: 10.1016/j.riam.2016.04.001. Epub 2016 Jun 11.
7
Comparison of the Sensititre YeastOne and CLSI M38-A2 Microdilution Methods in Determining the Activity of Amphotericin B, Itraconazole, Voriconazole, and Posaconazole against Aspergillus Species.比较 Sensititre YeastOne 和 CLSI M38-A2 微量稀释法测定两性霉素 B、伊曲康唑、伏立康唑和泊沙康唑对曲霉属的活性。
J Clin Microbiol. 2018 Sep 25;56(10). doi: 10.1128/JCM.00780-18. Print 2018 Oct.
8
Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document).CLSI 肉汤微量稀释法（M38-A2 文件）中三唑类药物和六种曲霉菌属的野生型 MIC 分布和流行病学折点值。
J Clin Microbiol. 2010 Sep;48(9):3251-7. doi: 10.1128/JCM.00536-10. Epub 2010 Jun 30.
9
MIC distributions for amphotericin B, fluconazole, itraconazole, voriconazole, flucytosine and anidulafungin and 35 uncommon pathogenic yeast species from the UK determined using the CLSI broth microdilution method.采用 CLSI 肉汤微量稀释法测定英国的两性霉素 B、氟康唑、伊曲康唑、伏立康唑、氟胞嘧啶和安尼卡fungin 以及 35 种罕见致病性酵母种的 MIC 分布。
J Antimicrob Chemother. 2020 May 1;75(5):1194-1205. doi: 10.1093/jac/dkz568.
10
In-vitro activity of voriconazole, itraconazole and amphotericin B against filamentous fungi.伏立康唑、伊曲康唑和两性霉素B对丝状真菌的体外活性。
J Antimicrob Chemother. 1998 Dec;42(6):741-5. doi: 10.1093/jac/42.6.741.
引用本文的文献
1
First case of invasive in a child with chronic granulomatous disease in Qatar.卡塔尔一名患有慢性肉芽肿病的儿童出现侵袭性感染的首例病例。
Med Mycol Case Rep. 2024 Oct 9;46:100675. doi: 10.1016/j.mmcr.2024.100675. eCollection 2024 Dec.
2
Cryptophytes as potential source of natural antimicrobials for food preservation.隐藻作为食品保鲜天然抗菌剂的潜在来源。
Front Microbiol. 2024 Sep 25;15:1462696. doi: 10.3389/fmicb.2024.1462696. eCollection 2024.
3
Does sorghum phenolic extract have antifungal effect?高粱酚提取物是否具有抗真菌作用？
Braz J Microbiol. 2024 Jun;55(2):1829-1839. doi: 10.1007/s42770-024-01327-9. Epub 2024 May 9.
4
Changes in fungal taxonomy: mycological rationale and clinical implications.真菌分类学的变化： mycological 原理和临床意义。
Clin Microbiol Rev. 2023 Dec 20;36(4):e0009922. doi: 10.1128/cmr.00099-22. Epub 2023 Nov 6.
5
Citizen science reveals landscape-scale exposures to multiazole-resistant bioaerosols.公民科学揭示了多烯抗性生物气溶胶的景观尺度暴露。
Sci Adv. 2023 Jul 21;9(29):eadh8839. doi: 10.1126/sciadv.adh8839.
6
Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates.牛磺罗定对毛霉目真菌的抗真菌活性：对临床分离株的体外研究。
Curr Med Mycol. 2022 Mar;8(1):26-31. doi: 10.18502/cmm.8.1.9211.
7
Rech. f. Mediated Fabrication of Gold Nanoparticles; Characterization and Evaluation of Antimicrobial, Antioxidant and Antidiabetic Potency of the Synthesized AuNPs.用于介导金纳米粒子合成的受体; 所合成的 AuNPs 的抗菌、抗氧化和抗糖尿病效力的表征和评估。
Molecules. 2022 Oct 7;27(19):6669. doi: 10.3390/molecules27196669.
8
Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis.毛霉病及与 COVID-19 相关的毛霉病：一种致命却被忽视的真菌病的见解
J Fungi (Basel). 2022 Apr 25;8(5):445. doi: 10.3390/jof8050445.
9
Recent Advances and Future Directions in the Understanding of Mucormycosis.黏菌病的研究进展及未来方向
Front Cell Infect Microbiol. 2022 Feb 24;12:850581. doi: 10.3389/fcimb.2022.850581. eCollection 2022.
10
and the Interplay with Amphotericin B: from Resistance to Tolerance?与两性霉素 B 的相互作用：从耐药到耐受？
Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0227421. doi: 10.1128/aac.02274-21. Epub 2022 Mar 7.
本文引用的文献
1
New pharmacological opportunities for the treatment of invasive mould diseases.侵袭性霉菌病治疗的新药理学机遇
J Antimicrob Chemother. 2017 Mar 1;72(suppl_1):i48-i58. doi: 10.1093/jac/dkx033.
2
Changes in the epidemiological landscape of invasive mould infections and disease.侵袭性霉菌感染与疾病的流行病学格局变化。
J Antimicrob Chemother. 2017 Mar 1;72(suppl_1):i5-i11. doi: 10.1093/jac/dkx028.
3
Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.烟曲霉全球范围内新出现的唑类耐药性的临床意义
Philos Trans R Soc Lond B Biol Sci. 2016 Dec 5;371(1709). doi: 10.1098/rstb.2015.0460.
4
Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review.伏立康唑治疗多育拟青霉肺炎 1 例并文献复习
Mycoses. 2016 Dec;59(12):746-750. doi: 10.1111/myc.12525. Epub 2016 Jul 12.
5
CD101: a novel long-acting echinocandin.CD101：一种新型长效棘白菌素。
Cell Microbiol. 2016 Sep;18(9):1308-16. doi: 10.1111/cmi.12640. Epub 2016 Jul 22.
6
International Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Method.采用CLSI肉汤微量稀释法通过分子方法鉴定的镰刀菌属菌种的最低抑菌浓度（MIC）分布及流行病学临界值（ECV）定义的国际评估
Antimicrob Agents Chemother. 2015 Dec 7;60(2):1079-84. doi: 10.1128/AAC.02456-15. Print 2016 Feb.
7
Echinocandins: The Expanding Antifungal Armamentarium.棘白菌素类药物：不断扩展的抗真菌药物武器库。
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S604-11. doi: 10.1093/cid/civ814.
8
Multicenter evaluation of MIC distributions for epidemiologic cutoff value definition to detect amphotericin B, posaconazole, and itraconazole resistance among the most clinically relevant species of Mucorales.多中心评估最小抑菌浓度（MIC）分布以确定流行病学临界值，用于检测毛霉目中最具临床相关性的菌种对两性霉素B、泊沙康唑和伊曲康唑的耐药性。
Antimicrob Agents Chemother. 2015 Mar;59(3):1745-50. doi: 10.1128/AAC.04435-14. Epub 2015 Jan 12.
9
Risk factors for invasive fusariosis in patients with acute myeloid leukemia and in hematopoietic cell transplant recipients.急性髓细胞白血病和造血细胞移植受者侵袭性镰刀菌病的危险因素。
Clin Infect Dis. 2015 Mar 15;60(6):875-80. doi: 10.1093/cid/ciu947. Epub 2014 Nov 25.
10
ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others.欧洲临床微生物学和感染病学会与欧洲癌症研究和治疗组织临床微生物学和真菌感染协作组：接合菌病诊治指南——镰孢菌属、枝顶孢属及其他。
Clin Microbiol Infect. 2014 Apr;20 Suppl 3:27-46. doi: 10.1111/1469-0691.12465.
Zotero 插件