Verma N P, Madhu S V
Lady Hardinge Medical College, New Delhi.
J Assoc Physicians India. 1992 Feb;40(2):84-6.
Thirty adults with essential hypertension (systolic BP greater than 150 mmHg or diastolic BP greater than 100 mmHg) were treated with 5-20 mg of enalapril to study its anti-hypertensive efficacy and safety. Ten patients had mild hypertension (diastolic BP greater than 90 mmHg and less than 105 mmHg), 10 had moderate hypertension (diastolic BP greater than 105 mmHg and less than 115 mmHg) and 6 had severe hypertension (diastolic BP greater than 115 mmHg). Of the 20 patients who completed the trial, 9 (45%) showed optimum reduction of BP to less than 130/90 mmHg) and a further 7 (35%) showed significant reduction. The mean fall in systolic BP was 32.5 mmHg (0-80 mmHg) and in diastolic BP was 18.5 mmHg (0-50 mmHg). The peak fall in BP was achieved in 3.5 weeks (1-6 weeks) with a mean dose of 7.2 mg of enalapril daily (5-15 mg/day). Mild side effects not needing drug withdrawal were seen in 8/20 patients (40%). Monotherapy with enalapril appears to be effective and safe as step one therapy for patients with essential hypertension.
30名原发性高血压成人患者（收缩压大于150 mmHg或舒张压大于100 mmHg）接受了5 - 20 mg依那普利治疗，以研究其降压疗效和安全性。10名患者为轻度高血压（舒张压大于90 mmHg且小于105 mmHg），10名患者为中度高血压（舒张压大于105 mmHg且小于115 mmHg），6名患者为重度高血压（舒张压大于115 mmHg）。在完成试验的20名患者中，9名（45%）血压最佳降低至130/90 mmHg以下，另有7名（35%）血压显著降低。收缩压平均下降32.5 mmHg（0 - 80 mmHg），舒张压平均下降18.5 mmHg（0 - 50 mmHg）。血压在3.5周（1 - 6周）时达到最大降幅，依那普利平均日剂量为7.2 mg（5 - 15 mg/天）。20名患者中有8名（40%）出现无需停药的轻微副作用。依那普利单药治疗作为原发性高血压患者的一线治疗似乎有效且安全。
