Johnston G D, Banks D C, Davies S, Duffin D, Garnham J C, Nicholls D P, Raj M V, Mansy S, Sloan P, Strouthidis T M
Queen's, University, Belfast.
J Hum Hypertens. 1991 Oct;5(5):405-10.
The efficacy and safety profiles of lisinopril (10-40 mg) and enalapril (5-20 mg) were compared in 169 hypertensive patients during 12 weeks' treatment in a randomised double-blind parallel group study. BP was measured hourly for the first 8 hours following the first dose of lisinopril 10 mg and enalapril 5 mg. The peak reduction in sitting systolic and diastolic BP occurred approximately 6 hours post dose in both groups. At 8 hours post dose lisinopril had reduced sitting systolic and diastolic BP by 2.9 mmHg and 3.5 mmHg (P = 0.02) respectively, more than enalapril with similar results for standing BP. One patient on enalapril developed first dose postural hypotension. After 12 weeks' therapy lisinopril produced a greater decrease (P less than 0.05) in BP than enalapril. Sitting BP decreased by 25/15 mmHg on lisinopril and 17/12 mmHg with enalapril. Standing BP decreased by 24/14 mmHg compared with 16/10 mmHg on enalapril. Eighteen patients did not complete the study, 8 on lisinopril (6 adverse events, 1 uncontrolled BP, 1 protocol violator) and 10 on enalapril (8 adverse events, 1 uncontrolled BP, 1 protocol violator). Overall, the results indicated that while both drugs are well tolerated, the dose range of lisinopril 10-40 mg may produce a greater antihypertensive effect than enalapril 5-20 mg.
在一项随机双盲平行组研究中，对169例高血压患者进行了12周治疗，比较赖诺普利（10 - 40毫克）和依那普利（5 - 20毫克）的疗效和安全性。在首次服用10毫克赖诺普利和5毫克依那普利后的头8小时内，每小时测量血压。两组坐位收缩压和舒张压的最大降幅均出现在给药后约6小时。给药后8小时，赖诺普利使坐位收缩压和舒张压分别降低了2.9毫米汞柱和3.5毫米汞柱（P = 0.02），比依那普利降低的幅度更大，立位血压结果相似。一名服用依那普利的患者出现了首剂体位性低血压。经过12周治疗后，赖诺普利使血压下降幅度大于依那普利（P小于0.05）。服用赖诺普利时坐位血压下降了25/15毫米汞柱，服用依那普利时下降了17/12毫米汞柱。立位血压下降了24/14毫米汞柱，而依那普利组为16/10毫米汞柱。18名患者未完成研究，8名服用赖诺普利（6例不良事件、1例血压未控制、1例违反方案），10名服用依那普利（8例不良事件、1例血压未控制、1例违反方案）。总体而言，结果表明，虽然两种药物耐受性都良好，但10 - 40毫克的赖诺普利剂量范围可能比5 - 20毫克的依那普利产生更大的降压效果。
