Koplan J P, Monsur K A, Foster S O, Huq F, Rahaman M M, Huq S, Buchanan R A, Ward N A
J Infect Dis. 1975 Jan;131(1):34-9. doi: 10.1093/infdis/131.1.34.
A double-blind study of the efficacy of adenine arabinoside in the treatment of patients with variola major was conducted. Adenine arabinoside (20 mg/kg of body weight) was given to patients intravenously every 24 hr for seven days in a 8-hr infusion. Five of the nine patients receiving adinine arabinoside died, and four of 11 patients receiving placebo died. Mortality was related to the severity of illness for both groups of patients. No difference was found between the drug and control groups in number of febrile days after initiation of therapy or in the period during which it was possible to isolate virus from skin lisions, throat swabs, and sources of clotted blood. Formation of scabs on skin lesions was complete 8.3 days after the initiation of therapy for the drug group and after 11.3 days for the control group. The findings suggest that adenine arabinoside is not effective in the chemotherapy of smallpox.
开展了一项关于阿糖腺苷治疗重症天花患者疗效的双盲研究。阿糖腺苷（20毫克/千克体重）以8小时静脉输注的方式，每24小时给患者用药一次，持续7天。接受阿糖腺苷治疗的9名患者中有5人死亡，接受安慰剂治疗的11名患者中有4人死亡。两组患者的死亡率均与疾病严重程度相关。在治疗开始后的发热天数或从皮肤损伤、咽拭子和血凝块中分离出病毒的时间段方面，药物组和对照组之间未发现差异。药物组皮肤损伤结痂在治疗开始后8.3天完成，对照组在11.3天后完成。研究结果表明，阿糖腺苷在天花化疗中无效。
