Zuber Guy, Muller Christian D, Behr Jean-Paul
Laboratoire de Chimie Genetique, Université Louis Pasteur, Faculté de Pharmacie, Illkirch, France.
Technol Cancer Res Treat. 2005 Dec;4(6):637-43. doi: 10.1177/153303460500400607.
Progress in the design of gene delivery system is vital for cancer gene therapy since many physiological and intracellular barriers remain. We have developed a technology for condensing genes into nanometric delivery systems. In this paper, we present a novel strategy for decorating 30 nm DNA particles with folic acid for cancer cell recognition. Physicochemical and biological experiments show that these DNA complexes selectively bind to cells expressing the corresponding folic acid receptor.
由于仍然存在许多生理和细胞内障碍，基因递送系统的设计进展对于癌症基因治疗至关重要。我们已经开发出一种将基因浓缩到纳米级递送系统的技术。在本文中，我们提出了一种用叶酸修饰30纳米DNA颗粒以识别癌细胞的新策略。物理化学和生物学实验表明，这些DNA复合物能选择性地与表达相应叶酸受体的细胞结合。
