Pan Dipanjan, Turner Jeffrey L, Wooley Karen L
Department of Chemistry, Washington University, One Brookings Drive, CB 1134, Saint Louis, Missouri 63130, USA.
Chem Commun (Camb). 2003 Oct 7(19):2400-1. doi: 10.1039/b307878g.
Shell cross-linked nanoparticles (SCKs) constitute a unique class of materials with amphiphilic core-shell morphology; SCKs are characterised by their structural integrity and available functionality to attach receptor-recognising or receptor-specific ligands on the shell surface and, therefore, hold great potential in drug delivery applications; in an attempt to develop novel, cancer cell specific delivery vehicles, folate receptor targeted SCKs have been prepared.
壳交联纳米粒子（SCKs）是一类具有两亲性核壳形态的独特材料；SCKs的特点是其结构完整性以及在壳表面连接受体识别或受体特异性配体的可用功能，因此在药物递送应用中具有巨大潜力；为了开发新型的癌细胞特异性递送载体，已制备了叶酸受体靶向的SCKs。
