Kuhn Hartmut
Institute of Biochemistry, Univsersity Medicine Berlin-Charite, Monbijou stra. 2, 0-10115 Berlin, Germany.
Expert Rev Cardiovasc Ther. 2005 Nov;3(6):1099-110. doi: 10.1586/14779072.3.6.1099.
Lipoxygenases (LOXs) form a heterogeneous family of lipid-peroxidizing enzymes, which have originally been implicated in cell differentiation and biosynthesis of inflammatory mediators. More recent studies suggested a role of various LOX-isoforms in the pathogenesis of human diseases, including bronchial asthma, osteoporosis and atherosclerosis. According to their phylogenetic relatedness, LOX-isoforms may be classified into four subfamilies, three of which (12/15-LOX, 5-LOX, platelet 12-LOX) have been related to atherogenesis. Several lines of experimental evidence suggest a role for LOXs in atherosclerosis, but the mechanisms remain a matter of discussion. This review will briefly summarize the current understanding on the molecular enzymology of the LOX family and the current status of knowledge on the role of different LOX isoforms in atherogenesis. The available literature data will be critically reviewed and a short perspective on future developments in the field will be provided.
脂氧合酶（LOXs）构成了一个脂质过氧化酶的异质家族，最初被认为与细胞分化和炎症介质的生物合成有关。最近的研究表明，各种LOX同工型在人类疾病的发病机制中发挥作用，包括支气管哮喘、骨质疏松症和动脉粥样硬化。根据它们的系统发育相关性，LOX同工型可分为四个亚家族，其中三个亚家族（12/15-LOX、5-LOX、血小板12-LOX）与动脉粥样硬化的发生有关。几条实验证据表明LOXs在动脉粥样硬化中发挥作用，但其机制仍存在争议。本综述将简要总结目前对LOX家族分子酶学的理解以及不同LOX同工型在动脉粥样硬化发生中作用的知识现状。将对现有文献数据进行批判性综述，并提供该领域未来发展的简短展望。
